Parathyroid pathoma 01-20 Flashcards
What secrete chief cells?
secrete PTh -> regulate calcium in serum
PTH on osteoclasts?
increase osteoclast activity -> incr. serum Calcium and PO4
PTH on small bowel?
increase Ca and PO4 reabsorbtion (INDIRECTLY BY ACTIVATING vit D).
PTH on renal?
Incr. Ca reabsobtion in distal tubule
and decr. reabsorbtion PO4 in proximal tubule
PTH. where in kidney calcium?
Incr. Ca reabsobtion in distal tubule
PTH. Decr PO4 in kidney where?
decr. PO4 reabsorbtion in proximal tubule
PTH regulation?
increased serum Ca negative feedback to decrease PTH secretion
Primary hyperparathyroidism. Mechanism?
Excess of PTH due to primary disorder of the PARATHYROID GLAND
Primary hyperparathyroidism. most common cause?
parathyroid adenoma - benign neoplasm, usually involve one gland
sporadic hyperplasia and carcinoma is less common
Primary hyperparathyroidism. symptoms in general?
asymptomatic hypercalcemia
Primary hyperparathyroidism. kidney?2
nephrolithiasis calcium oxalate);
Nephrocalcinosis - metastatic calcification of renal tubules -> renal insuf., and polyuria
Primary hyperparathyroidism. cns?
CNS disturbances - depression, seizures
Primary hyperparathyroidism. gut?
constipation, peptic ulcer disease, acute pancreatitis
Primary hyperparathyroidism. bones?
osteitis fibrosa cystica - reabsorbtion of bone leading to fibrosis and cystic spaces
Primary hyperparathyroidism. lab? PTH, Ca, PO4, urinary cAMP, ALP?
incr. PTH, incr. Ca, decr. PO4, incr. urinary cAMP, incr. ALP (due to osteo
