Primary ANS receptors Flashcards

1
Q

Cholinoreceptors

A

-acetylcholine receptors
-nicotinic or muscarinic

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2
Q

Adrenoceptors

A

-norepinephrine and epinephrine receptors
-alpha or beta

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3
Q

Primary ANS receptors

A

-cholinoreceptors
-adrenoreceptors

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4
Q

Nicotinic Receptors

A

-5 subunits ionotropic Na+ ion channel
-ligand-gated
-activated by nicotine
-ganglionic, skeletal muscle, neuronal CNS

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5
Q

Nicotinic receptor mech

A

-opening leads to depolarization of membrane
= opens Na+ channels to produce action potential

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6
Q

Muscarinic receptors

A

-GPCR
-7 transmembrane domain
-M1-M5
-Gq pathway or G1 pathway

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7
Q

Gq pathway

A

-IP3 mobilize intracellular Ca++
-DAG, activate Protein kinase C

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8
Q

M1, M3, M5 signal via

A

Gq pathway

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9
Q

Gi pathway

A

-inhibitory
-adenylyl cyclase to cAMP to protein kinase

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10
Q

M2 and M4 signal via

A

Gi pathway

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11
Q

Adrenergic receptors in ANS

A

-a1 (a1A, a1B, a1D)
-a2
-B (B1, B2, B3)

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12
Q

a1 receptor signals via

A

-Gq pathway
-mediates vasoconstriction

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13
Q

a1 receptor distribution

A

-smooth muscle
-heart
-liver

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14
Q

a2 receptor signals via

A

-Gi pathway (inhibitory)
-inhibt adenylyl cyclase
-reduce cAMP-dependent protein kinase
-activate certain K+ channels

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15
Q

a2 receptors

A

-found pre-synaptically
-autoreceptors to inhibit sympathetic output which decreases transmitter release

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16
Q

B receptors signal via

A

-Gs
-activate adenylyl cyclase
-increase cAMP
=phosphorylation of ion channels and other protein

17
Q

M2 and M4 interactions

A

-counteract B1 receptors
-K+ channel opens that causes hyperpolarization

18
Q

ANS major regulator of

A

-blood pressure
-heart function
-bronchoconstriction/dilation

19
Q

ANS and pharmacology

A

-many drugs with anticholinergic effects (important for elderly)
-cholinergics in pesticides and chemical weapons

20
Q

Adrenergic response of heart

A

-rate and force of contraction INCREASE
-receptor B1>B2

21
Q

Cholinergic response of heart

A

-rate and force of contraction DECREASE
-receptor M2

22
Q

Adrenergic response of blood vessels

A

-arteries and veins vasoCONSTRICT
-skeletal muscle vasoDILATES

23
Q

artery adrenergic response

A

-a1
-vasoCONSTRICT

24
Q

vein adrenergic response

A

-a1,2
-vasoCONSTRICT

25
Q

skeletal muscle adrenergic reponse

A

-B2
-vasoDILATE

26
Q

Predominantly Sympathetic

A

-arterioles
-veins
-sweat glands

-no PSNS innervation

27
Q

Predominantly parasympathetic

A

-heart
-eyes: iris and ciliary
-GI tract
-bladder
-salivary

28
Q

SLIDE 44

A

SLIDE 44 v important