15. Metabolically Healthy Obese Flashcards Preview

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Flashcards in 15. Metabolically Healthy Obese Deck (11):
1

MHO and MUHO charaterizations

differences in body composition
- visceral fat
- more inflammation in adipocyte
- inflammasome and immune cells
- worse fitness performance

2

metabolically unhealthy obese
- metabolites

visceral adipose tissue (VAT) increased metabolites:

1. IL-1B
- pro inflammatory cytokine

2. NLRP3
- inflammasome
- coorelated with insulin resistance

*expression of these metabolites not increased in subcutaneous adipose tissue

3

immune cell types in adipose tissue in MUHO

T cells (T regs) reduction in VAT

4

Pro inflammatory cytokine

IL-1 beta (interleukin 1 beta)
- increases in VAT with MUHO
- produced by marcophages isolated from VAT

5

Inflammasome

NLRP3
- increases in VAT with MUHO

6

enzyme that proteolytically cleaves proteins forming pro inflammatory cytokines

caspase-1
- part of inflammasome
- drives pro inflammatory cytokine release
- IL-1 beta
- increased in VAT only with MUHO

7

NLRP3 knockout

IL-1 beta and IL-18 reduction
- reduction in pro inflammatory cytokine production

need inflammasome to produce pro inflammatory cytokine

8

omega 3 (DHA) and inflammasome

suppressed NLRP3 activation
- inflammasome activation
- IL-1 beta reduction

* needs NLRP3 to be present to have effect
- proves this is where it is acting

9

omega 3 (DHA) other mechanisms of action

adiponectin
- reduced inhibition in high SFA diet
- restored impaired insulin action

10

HIIT and mediteranian diet intervention
- both MHO and MUHO
- 9 month study

MUHO reduced by 17.91%
- changes MUHO to MHO

Improved
- body compostion
- blood pressure
- fasting blood glucose
- insulin sensitivity
- VO2 peak
- muscle endurance

11

MHO relative risk

30-50% reduction mortality and morbidity