7. integrative metabolism protein Flashcards Preview

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Flashcards in 7. integrative metabolism protein Deck (12):
1

why protein requirement is small

high turnover between synthesis, degradation and conversion
- most of breakdown is recycled

2

fate of protein

1. formation of glutamate and alanine
- forms alpha-ketoglutarate for krebs cycle

2. urea production
- excreted, increases with exercise, escpecially carb depleted

3. branched chained amino acids
- lecuine, isoleucine, valine
- increase in muscle in proportion to aerobic exercise intensity

3

central fatigue hypothesis

increase BCAA plasma concentration
reduce Trp uptake
less serotonin production
-- less rapid fatigue

little evidence supporting this theory

4

affect of insulin on protein metabolism

increase synthesis
decrease degredation

5

CHO ingestion with amino acids

raises insulin levels

leucine very effective at increasing insulin levels

6

feature of whey protein

high in leucine
- large insulin increase

7

Aerboic exercise and protein synthesis, degredation and oxidation

synthesis
- decreased during prolonged aerobic exercise
- increased during recovery from prolonged exercise

degredation
- increased BUT not contractile protein (actin/myosin)

oxidation
- 2-6% total energy provision

8

resistance exercise with protein metabolism

stimulates synthesis and breakdown
- increased turnover 24 - 48 hrs post exercise
- if not enough food, degredation exceeds synthesis
* eat more protein and AAs

9

type of amino that promote protein synthesis

essential amino acids
- non essential no benefit
- leucine largest contributor

10

whey vs casein protein

whey
- quick transient increase in protein synthesis
- higher leucine in whey
- larger insulin
- rapid gastric emptying (AA in blood)

casein
- prolonged increase blood AA and net positive protein balance

*no difference in protein synthesis
- measured by nitrogen balance and Phe uptake
- whey maybe better b/c of larger insulin increase

11

addition of carb to amino acids

no benefit
- insulin increase more but no change in muscle protein synthesis (MPS)

12

aminos with greatest effect on insulin secretion

leu, phe, and arg