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Flashcards in 15 Systematic Reviews Deck (14)
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1

4 reasons to do systematic reviews

Response to calls to organize knowledge
Efficient way to access a specific body of research
Explore differences between studies
Reliable basis for decision making

2

Evidence informed healthcare takes what 3 things into account?

Clinical expertise
Patient's values
Research evidence

3

Narrative vs systematic reviews
1. Question
2. Sources and searches
3. Selection

1. NR: broad, SR: focused clinical question
2. NR: not specified, biased, SR: comprehensive source and strategy explicitly stated
3. NR: not specified, biased, SR: criterion-based, uniformly applied

4

Narrative vs systematic reviews
1. Appraisal
2. Synthesis
3. Inferences

1. NR: variable, SR: rigorous critical appraisal
2. NR: qualitative summary common. SR: qualitative summary plus or minus meta analyis
3. NR: sometimes evidence based, SR: evidence-based

5

What are systematic reviews?

Synthesis of results of all available studies
Address a focused question
Use systematic and explicit methods to identify, select and appraise relevant research and collect/analyze data
Minimize potential biases at each step
They use well-defined protocol and methodological principles to attempt to reduce bias

6

5 advantages of systematic reviews

Digest large amounts of information
Assess consistency of results
Improve ability to detect an experimental effect
Increase precision in estimate of effect
Reduce random errors

7

5 potential disadvantages of systematic reviews

Can be difficult to read and interpret
A poor systematic review may be given greater precedence than a well conducted RCT
The inclusion of inappropriate studies can lead to drowning of important effects
Increase systematic errors
Limited by reporting quality

8

Time required for a systematic review

6 months
1200 hours

9

5 steps of a systematic review

Formulate the review question
Identify studies
Select studies for inclusion
Appraise included studies
Synthesize the results

10

PICOS

Population
Intervention (exposure)
Comparison
Outcome
Study designs

11

Importance of the review question (3)

Transparency
Minimises bias
Facilitates subsequent steps

12

Which step is the key factor distinguishing systematic reviews from narrative reviews?

Identifying studies
Use a comprehensive literature search

13

3 different analytical methods

Narrative synthesis
Meta-analysis
Meta regression +

14

Meta-analysis

Statistical analysis of a collection of independent studies
Quantitative part of systematic reviews