HEART LECTURE Flashcards

1
Q

What is the cardiovascular system made up of?

A

the cardiovascular system is made up of the heart and the blood vessels

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2
Q

What are the three types of blood vessels?

A

the three types of blood vessels are the veins, arteries, and capillaries

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3
Q

What is the heart?

A

a four-chambered muscular pump

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4
Q

What is the function of the arteries?

A

arteries are responsible for carrying blood away from the heart

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5
Q

What is the function of the veins?

A

veins are responsible for carrying blood to the heart

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6
Q

What are capillaries?

A

capillaries are tiny networks of veins and arteries that supply blood

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7
Q

What are the two subdivisions of the cardiovascular system?

A

the cardiovascular system is divided into the pulmonary circuit and the systemic circuit

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7
Q

What is the function of the pulmonary circuit?

A

the pulmonary circuit carries deoxygenated blood to the lungs for gas exchange and returns oxygenated blood to the heart

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8
Q

Which side of the heart makes up the pulmonary circuit?

A

the right side of the heart makes up the pulmonary circuit

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9
Q

Which vessels does the pulmonary circuit use in order to transport deoxygenated blood?

A

the pulmonary circuit uses the pulmonary arteries in order to transport deoxygenated blood to the lungs

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10
Q

Which vessels does the pulmonary circuit use in order to transport oxygenated blood?

A

the pulmonary circuit uses pulmonary veins in order to transport oxygenated blood to the heart

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11
Q

What is the function of the systemic circuit?

A

the systemic circuit is responsible for supplying oxygenated blood to the entire body and returning deoxygenated blood to the heart

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12
Q

Which side of the heart makes up the systemic circuit?

A

the left side of the heart makes up the systemic circuit

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13
Q

Which vessel does the systemic circuit use to supply oxygenated blood to the body?

A

the systemic circuit utilizes the aorta to supply oxygenated blood to the body

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14
Q

Which vessels does the systemic circuit use in order to return deoxygenated blood to the heart?

A

the systemic circuit uses the superior/ inferior vena cava to return deoxygenated blood to the heart

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15
Q

Where is the heart located?

A

the heart is located in the mediastinum of the thoracic cavity (between the lungs)

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16
Q

How large is the heart?

A

the heart is approximately the same size as your fist; weighing ~10oz

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17
Q

What is the positioning of the heart?

A

the inferior portion of the heart (the apex) is slightly tilted left

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18
Q

What is the pericardium?

A

the pericardium is the tough fibrous tissue sac that encloses the heart

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19
Q

What fluid is the pericardium filled with?

A

the pericardium is filled with pericardial fluid

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20
Q

What is the function of pericardial fluid?

A

pericardial fluid allows the heart to beat with relatively no friction

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20
Q

What is the clinical condition: percarditis

A

pericarditis is an inflammation of the pericardium

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21
Q

What is the cause of percarditis?

A

pericarditis is due to dryness of the membrane and increased friction during each heartbeat

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22
Q

What are the three layers of the heart?

A

the three layers of the heart are the epicardium, myocardium, and endocardium

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23
Q

What is the epicardium layer of the heart?

A

the epicardium is the thin, smooth and moist serous layer; most superficial

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23
Q

What is the myocardium layer of the heart?

A

the myocardium is the thick, cardiac muscle of the heart; middle layer

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23
Q

Where does the contraction of the heart occur?

A

contraction of the heart occurs in the myocardium

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24
Q

What is the endocardium layer of the heart?

A

the endocardium is the smooth, inner lining of the chambers and valves; most deep

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25
Q

Where are the right/ left atria located?

A

the right/ left atria are the most superior chambers of the heart; superior to the ventricles

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26
Q

What is the function of the right/ left atria

A

the right/ left atria receive blood returning to the heart and pump it into the ventricles

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27
Q

What is the function of the interatrial septum?

A

the interatrial septum is responsible for separating the right/ left atria from each other

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27
Q

Where are the right/ left ventricles located?

A

the right/left ventricles are the inferior chambers of the heart; inferior to the atria

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28
Q

What is the function of the right/ left ventricles?

A

the right/ left ventricles are responsible for pumping blood into the arteries

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28
Q

Describe the muscular walls of the atria.

A

the atria have thin muscular walls

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29
Q

Describe the muscular walls of the ventricles.

A

the ventricles have thick muscular walls; especially the left ventricle

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30
Q

Why is the left ventricle wall significantly thicker than its neighboring chambers?

A

the left ventricle wall is responsible for pumping the blood further away from the heart; requiring more force output

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31
Q

What is the interventricular septum?

A

the interventricular septum separates the right/ left ventricles

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32
Q

What is the function of the heart valves?

A

the heart valves ensure that blood flows in only one direction

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33
Q

What is the function of the atrioventricular valves?

A

the atrioventricular valves prevent backflow from the ventricles to the atria

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34
Q

What is another term for the right atrioventricular valve?

A

another term for the right atrioventricular valve is the tricuspid valves

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35
Q

What is another term for the left atrioventricular valve?

A

another term for the left atrioventricular valve is the bicuspid/ mitral valve

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36
Q

What does the acronym LAMB stand for?

A

the acronym “lamb” stands for “left atrium mitral/ bicuspid”

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37
Q

What are chordae tendineae?

A

chordae tendineae are string-like cords that attach the valves to papillary muscles of the floor of the ventricles

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38
Q

What is the function of the semilunar valves?

A

the semilunar valves are responsible for preventing backflow from the great arteries into the ventricles

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39
Q

How many cusps do the semilunar vales have?

A

the semilunar valves have three cusps

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40
Q

What is the first step of valve mechanics?

A

the first step of valve mechanics occurs when the ventricles relax and pressure drops; the semilunar valves close and the atrioventricular valves open allowing blood to flow into the ventricles from the atria

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41
Q

What is the second step of valve mechanics?

A

the second step of valve mechanics occurs when the ventricles contract and the atrioventricular valves close; pressure and the semilunar valves open causing blood to flow into the great arteries

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42
Q

What is the function of papillary muscles during the second step of valve mechanics?

A

the papillary muscles are responsible for contracting and pulling on the chordae tendineae to prevent prolapse

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43
Q

How many steps are there to valve mechanics?

A

valve mechanics is a two step process

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44
Q

What is a heart murmur?

A

a heart murmur is the regurgitation (backward flow) of blood through valves that are not functioning properly

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45
Q

Describe the pathway of blood in a way that starts and end in the right atrium.

A
  • right atrium
  • right atrioventricular valve
  • right ventricle
  • pulmonary semilunar valve
  • pulmonary arteries
  • lungs
  • pulmonary veins
  • left atrium
  • left atrioventricular valve
  • aortic semilunar valve
  • aortic artery
  • anatomical systems
  • superior/ inferior vena cava
  • right atrium
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46
Q

What is the function of the coronary circulation?

A

the function of the coronary circulation is to nourish the heart wall/ every cell in the myocardium

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47
Q

What makes up the coronary circulation?

A

the coronary circulation is made up of blood vessels

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48
Q

Describe the amount of time the heart beats over the course of one human life span.

A

the heart rate of the average person is 75 beats/ min for 80 years; at rest the heart beats ~3 billion times

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49
Q

How many primary branches does the left coronary artery have?

A

the left coronary artery has two primary branches

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50
Q

What is the function of the anterior interventricular artery?

A

the anterior interventricular artery supplies the anterior walls of the right/ left ventricles with blood vessels

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51
Q

What is another term for the left anterior interventricular artery and why?

A

the left anterior interventricular artery is also known as the “widow maker” because it is the primary causation of myocardial infarctions (heart attacks)

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52
Q

What is the function of the circumflex artery?

A

the circumflex artery is responsible for supplying the left atrium and posterior wall of the left ventricle with blood

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53
Q

What side of the heart does the circumflex artery pass over?

A

the circumflex artery passes over the left side of the heart

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54
Q

How many primary branches does the right coronary artery have?

A

the right coronary artery is made up of two primary branches

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55
Q

What two vessels make up the primary branches of the left coronary artery?

A

the two vessels that make up the primary branches of the left coronary artery are the anterior interventricular artery and the circumflex artery

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56
Q

What two vessels make up the primary branches of the right coronary artery?

A

the two vessels that make up the primary branches of the right coronary artery are the right marginal artery and the posterior interventricular artery

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57
Q

What is the function of the right marginal artery?

A

the right marginal artery is responsible for supplying the right atrium and right ventricle with blood

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58
Q

Which side of the heart does the right marginal artery pass over?

A

the right marginal artery runs toward the apex of the heart but originates on the hearts lateral side; located anteriorly

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59
Q

What is the function of the posterior interventricular artery?

A

the posterior interventricular artery is responsible for supplying the posterior walls of the ventricle with blood

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60
Q

Which side of the heart does the posterior interventricular artery of the heart run towards?

A

the posterior interventricular artery runs toward the apex of the heart

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61
Q

Which two coronary vessels form an anastomosis on the posterior portion of the heart?

A

the two coronary vessels that form an anastomosis of the posterior end of the heart are the posterior interventricular artery and the anterior interventricular artery

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62
Q

What is a myocardial infarction?

A

a myocardial infarction is the sudden death of heart tissue

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63
Q

What is the cause of a myocardial infarction?

A

myocardial infarctions are a result of the sudden closing of a coronary blood vessel causing lack of blood flow

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64
Q

What is the clinical condition: angina pectoris

A

angina pectoris is a reversible sense of heaviness or chest pain

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65
Q

When is angina pectoris most often experienced?

A

angina pectoris is often experiences during and episode of myocardial ischemia

66
Q

What is myocardial ischemia?

A

myocardial ischemia is a lack of blood flow in the heart

67
Q

What does is mean for something to be hypoxic?

A

to be hypoxic means it is lacking oxygen

68
Q

What is an anastomosis?

A

an anastomosis is a connection between two arteries

69
Q

What is the function of an anastomosis?

A

an anastomosis is responsible for creating an alternative pathway for blood to flow to a certain area of the body

70
Q

What percentage of the venous drainage enters the right ventricle?

A

20% of the venous drainage enters the right ventricle

71
Q

What percentage of the venous drainage returns to the right atrium by way of the coronary sinus?

A

80% of the venous drainage returns to the right atrium by way of the coronary sinus

72
Q

What are the characteristics of cardiac muscle?

A

characteristics of cardiac muscle consist of it being short, thick with one nucleus; it also has actin-myosin and t-tubules with cations

73
Q

What are intercalated disks?

A

intercalated disks are thick connections that connect the myocytes end-to-end

74
Q

What is happens to the cardiac cells if an individual cell becomes active?

A

if one cardiac cell becomes active the rest become active as well

75
Q

What is the function of electrical gap junctions?

A

electrical gap junctions form channels that allow ions to move from cell to cell

76
Q

Why is the electrical gap junction so important within the cardiac muscle (heart)?

A

the electrical gap junction allow one cell to stimulate its neighbors so that the entire myocardium acts as though it were a single cell

77
Q

What sort of energy does the heart need in order to contract?

A

the heart depends almost exclusively on aerobic regulation to produce ATP

78
Q

True or False: the heart is unable to be fatigued

A

true; a healthy heart does not fatigue

79
Q

What is aerobic respiration?

A

aerobic respiration is the process of using oxygen to fuel something

80
Q

What is anaerobic respiration?

A

anaerobic respiration is the process of not using oxygen to fuel something

81
Q

What are the characteristics of the hearts metabolism?

A

the heart contains myoglobin stores, glycogen, mitochondria, and fatty acids

82
Q

What is the function of myoglobin in the heart?

A

the myoglobin within the heart is responsible for storing oxygen

83
Q

What is the function of the glycogen in the heart?

A

the glycogen within the heart is responsible for storing carbohydrates

84
Q

What is the function of the mitochondria within the heart?

A

the mitochondria fill ~25% of the cardiac cells and are responsible for creating power

85
Q

What is the function of the fatty acids within the heart?

A

the fatty acids within the heart are responsible for providing another method of fuel to the heart

86
Q

What does the term “myogenic” mean?

A

the terms “myogenic” means that the heartbeat originates within the heart

87
Q

What does the term “autorhythmic” mean?

A

the term “autorhythmic” suggests that something produces regular but spontaneous acts of depolarization

88
Q

What is the function of the sinoatrial (sa) node?

A

the sinoatrial node is responsible for initiating the heartbeat and setting the hearts rate; the pacemaker

89
Q

Where is the sinoatrial node located?

A

the sinoatrial node is located in the right atrium

90
Q

What is the function of the atrioventricular (av) node?

A

the atrioventricular node is a second (and slightly slower) method of depolarization; relative to the sinoatrial node

91
Q

What is the function of the atrioventricular (av) bundle/ bundle of his?

A

the atrioventricular bundle/ bundle of his is responsible for being a pathway for electrical signals from the atrioventricular node

91
Q

Where is the sinoatrial node located?

A

the sinoatrial ode is located in the interatrial septum

92
Q

What are the right/left bundle branches?

A

the right/ left bundle branches are divisions of the atrioventricular bundle that enter the interventricular septum and descend to the heart apex

93
Q

What are the purkinje fibers?

A

the purkinje fibers are fibers that extend upward from the apex and spread throughout the ventricles

94
Q

What is a cardiac rhythm?

A

a cardiac rhythm is the repeating pattern of contraction and relaxation of the heart

94
Q

What happens to the heart is its systolic phase?

A

in the systolic phase of the heart, the heart contracts

95
Q

what happens in the diastolic phase of the heart?

A

in the diastolic phase of the heart. the heart relaxes

96
Q

When does atrial contraction occur?

A

atrial contraction (systole) occurs during ventricular relaxation (diastole); visa versa

97
Q

How long does it take the ventricles to contract after the atriums have contracted?

A

after the atriums have contracted, it takes ~0.1s for the ventricles to contract

98
Q

What controls the sinus rhythm?

A

the sinus rhythm is controlled by the sinoatrial node

99
Q

What is the average heartbeat of an adult at rest?

A

the heart of and adult at rest typically beats ~70-80 beats/mm

100
Q

What is heart arrhytmia?

A

heart arrhythmia is abnormal cardiac rhythm

101
Q

What is the common causation of arrhythmia (heart block)?

A

the failure if any part of the heart conduction system to transmit signals is usually the result of disease

102
Q

Describe the resting membrane potential of the heart.

A

the resting membrane potential of the heart is not stable and begins at ~60mV while slowly depolarizing due to a slow influx of na+

103
Q

What is the “pacemaker potential” of the cardiac muscle?

A

the “pacemaker potential” is the slow depolarization of the hearts resting membrane potential

104
Q

When does cardiac action potential occur?

A

cardiac action potential occurs at a threshold of ~-40mV

105
Q

Which ion channels open during cardiac depolarization?

A

during cardiac depolarization, voltage-gated ca+ channels open; ca+ flows in

106
Q

Which ion channels open during cardiac repolarization?

A

during cardiac repolarization, k+ channels open; k+ flows out

107
Q

What is the threshold that needs to be reached before cardiac depolarization starts over again?

A

at -60mV k+ channels close and the cardiac depolarization cycle starts again

108
Q

Describe the process of impulse conduction to the myocardium.

A

the sinoatrial node travels quickly through the atria where the atrioventricular node slows the signal down and allows the ventricles to fill with blood; afterwards the atrioventricular bundle and purkinje fibers move the signal along the ventricles

109
Q

Why is it important that ventricular contraction is initiated at the beginning of the apex and spreads upwards?

A

it’s important that ventricular contraction starts at the apex because the blood needs to pushed upwards/ outwards into the pulmonary trunk and aorta

110
Q

What are monocytes?

A

monocytes are the contractile cells of the myocardium

111
Q

what is the resting membrane potential of monocytes?

A

monocytes have a stable resting membrane potential of ~-90mV

112
Q

What causes the “plateau” of the myocardial contractions to occur?

A

the “plateau” is caused by Ca2+ voltage-gated channels; prolongs the contraction

113
Q

What causes depolarization of the myocardium?

A

depolarization of the is caused by voltage-gated na+ channels

114
Q

What causes the repolarization of the myocardium to occur?

A

repolarization of the myocardium occurs when ca+2 channels close and voltage-gated k+ channels open; the cell returns to resting membrane potential

115
Q

What is an electrocardiogram (ecg/ ekg)?

A

an electrocardiogram is the recording of electrical changes that occur in the myocardium during a cardiac cycle

116
Q

What does the p-wave on an electrocardiogram reflect?

A

the p-wave reflects the depolarization of the atria

117
Q

What does the qrs-complex on an electrocardiogram reflect?

A

the qrs-complex reflects the depolarization of the ventricles

118
Q

What does the t-wave on an electrocardiogram reflect?

A

the t-wave reflect the repolarization of the ventricles

119
Q

Which part of the cardiac cycle is not reflected on an electrcardiogram?

A

atrial repolarization occurs but is not reflected on an electrocardiogram

120
Q

What does an abnormal electrocardiogram suggest?

A

an abnormal electrocardiogram suggests that there are electrical conduction problems and approaching myocardial infarction (heart attack)

121
Q

Describe the cardiac cycle.

A

the cardiac cycle consists of one complete contraction and the relaxation of all four chambers of the heart

122
Q

When does atrial contraction of the cardiac cycle occur (in relation to the ventricles)?

A

atrial contraction occurs while the ventricles are relaxed

123
Q

When does ventricular contraction of the cardiac cycle occur (in relation to the atriums)?

A

ventricular contraction occurs while the atria are relaxed

124
Q

What is the quiescent period of the cardiac cycle?

A

the quiescent period of the cardiac cycle occurs when all chambers are relaxed/ inactive

125
Q

Describe the cardiovascular system in reference to the vessels and their relationship to the heart.

A

the cardiovascular system is plumbing network of vessels (arteries and veins) with a motor (the heart) circulating the blood

126
Q

Describe the process the heart needs to undergo in order to eject blood.

A

to eject blood the right/ left ventricles need to generate a pressure that is greater than the pressure within the major arteries

127
Q

What sound does the heart make when it beats?

A

the heart makes a “lubb-dubb” sound when it beats

128
Q

what is the “lubb” sound the heart makes indicative of?

A

the “lubb” sound indicates that the atrioventricular valves are closing

129
Q

what is the “dubb” sound the heart makes indicative of?

A

the “dubb” sound indicates the closing of the semilunar valves

130
Q

What is the first phase of the cardiac cycle?

A

the first phase of the cardiac cycle is the quiescent period

131
Q

What is the second phase of the cardiac cycle?

A

the second phase of the cardiac cycle is atrial systole

132
Q

What occurs during the quiescent period of the cardiac cycle?

A

during the quiescent period all chambers are relaxed and blood flows from the atria into the ventricles

133
Q

What occurs during the atrial systole phase of the cardiac cycle?

A

the sinoatrial node fires and the atria depolarizes; the p-wave appears on the electrocardiograph while the atria contract and force additional blood into the ventricles

134
Q

What is the end-diastolic volume (edv)?

A

the end-diastolic volume is the total amount of blood in ech ventricle after atrial systole - contraction; typically ~130ml

135
Q

Describe the process of isovolumetric contraction in reference to the ventricles.

A

the atria repolarizes and relaxes followed by the depolarization of the ventricles,
afterwards the ventricles contract and the rising pressure causes the atrioventricular valves to close; blood has yet to be ejected

136
Q

Describe the process of ventricular ejection.

A

rising pressure in the ventricles open the semilunar valves causing a rapid ejection of the blood leading to a reduced ejection as pressure drops

137
Q

What is stroke volume (sv)?

A

stroke volume is the amount of blood ejected by each ventricle after contraction

138
Q

What is the average stroke volume?

A

the average stroke volume is ~70mL at rest

139
Q

What is an ejection fraction (ef)?

A

ejection fraction is the percentage of blood ejected by each ventricle

140
Q

Describe the ejection fraction at rest, during exercise, and with a diseased heart.

A

the ejection fraction during rest is ~54%, during exercise it’s ~90%, and in a diseased heart it is less than 50%

141
Q

What is the end-systolic volume (esv)?

A

end-systolic volume is the amount of blood remaining in each ventricle following ventricular systole (contraction)

142
Q

Describe the process of isovolumetric relaxation of the muscles.

A

ventricles repolarize and relax followed by the semilunar valves closing,
the atrioventricular valves remain closed and the ventricle expand but don’t fill; the process starts over

143
Q

What is cardiac output (q)?

A

cardiac output is the amount of blood ejected by each ventricle in one minute

144
Q

What is the equation for cardiac output?

A

cardiac output = heart rate x stroke volume (the amount of blood pumped per beat)

145
Q

What is the equation for finding the average resting cardiac output?

A

heart rate (75 beats/min) x stroke volume (70 ml/beats) = 5.0 L/min

146
Q

What is the equation for finding the max exercise cardiac output?

A

heart rate (200 beats/min) x stroke volume (110 ml/beats) = 22 L/min

147
Q

How is the heart rate measured?

A

the heart rate is measured from pulse

148
Q

What is the average heart rate for infants?

A

the average heart rate for infants is less than 120 beats/min

149
Q

What is the average heart rate for adults?

A

the average heart rate for adults is
60 - 80 beats/min

150
Q

What does the term “tachycardia” suggest?

A

the term “tachycardia” suggests a persistent heart rate of more than 100 beats/ min

151
Q

What are the likely causes of tachycardia?

A

likely causes of tachycardia are high levels of stress, anxiety, use of drugs, or disease

152
Q

What dies the term “brachycardia” suggest?

A

the term “brachycardia” suggests a persistent heart rate of less than 60 beats/ min

153
Q

What are likely causes of brachycardia?

A

likely causes of brachycardia are that the individual is sleeping or is an endurance athlete

154
Q

How is the regulation of heart rate determined?

A

the regulation of heart rate is determined by the tissues need of oxygen

155
Q

What does the term “intrinsic” indicate in reference to heart rate?

A

the term “intrinsic” in reference to heart rate indicates that the sinoatrial node sets the resting heart rate

156
Q

What does the term “extrinsic” indicate in reference to heart rate?

A

the term “extrinsic” indicates that the autonomic nervous system can modify the heart rate

157
Q

Where is the cardioacceleratory center housed?

A

the cardioacceleratory center is housed in the medulla oblongata

158
Q

What is the first step of the cardioacceleratory center if it is trying to modify the heart rate?

A

the first step is that the sympathetic neurons from the cardiac plexus innervate the sinoatrial and atrioventricular nodes, myocardium, and coronary arteries

159
Q

What is the second step of the cardioacceleratory center if it is trying to modify the heart rate?

A

the second step it that when stimulated the sympathetic neurons release norepinephrine that attaches to the beta-receptors and causes an increases heart rate and force of contraction

160
Q

What are beta-blockers?

A

beta-blockers are drugs that prevent and increase in the heart rate by blocking beta-receptors on the heart cell

161
Q

Where is the cardioinhibitory center located?

A

the cardioinhibitory center is housed in the medulla oblongata and arises from neurons in the medulla to make up the vagus nerve

162
Q

What is the first step of the cardioinhibitory center if it’s trying to modify the heart rate?

A

the parasympathetic neurons innervate the sinoatrial and atrioventricular nodes through the vagus nerve

163
Q

What is the second step of the cardioinhibitory center if it’s trying to modify the heart rate?

A

when the sinoatrial and atrioventricular nodes are stimulated, acetylcholine is released causing a decrease in activity for both nodes and slowing the heart rate

163
Q

Why does the release of acetylcholine during cardio inhibition cause a decrease in activity?

A

the release of acetylcholine causes a decrease in activity because it moves the resting membrane potential further from the threshold/ hyperpolarizes it

163
Q

What is the function of receptors in reference to the cardiovascular system?

A

receptors regularly send information to the higher brain center

163
Q

What is the function of baroreceptors?

A

baroreceptors are responsible for sending continuous signals to the cardiac center of the brain

163
Q

What are baroreceptors?

A

baroreceptors are pressure sensor in the aorta and carotid vessels