Codeine Flashcards
1
Q
What class of drug is codeine?
A
Opiate
Natural opioid
2
Q
What are the uses of codeine?
A
- analgesic
- cough suppression
- anti-diarrhoea
3
Q
What is the mechanism of action of codeine?
A
- Binds to u receptors to stimulate the release of dopamine
- converted to morphine by CYP2D6 enzymes
4
Q
What are adverse drug reactions of codeine?
A
- constipation + urinary retention
- flushing + headaches
- hyperhidrosis
- miosis
- nausea
- respiorty depression
5
Q
What are important drug drug interactions of codeine?
A
- other CNS depressants e.g. AEDs or benzos
- other opioid containing drugs
- CYP enzyme inhibitors
