Lecture 24- EPSPs, IPSPs, Synaptic Integration Flashcards
What is an EPSP?
Excitatory Post Synaptic Potential
A postsynaptic potential that makes the postsynaptic neuron more likely to fire an action potential
The first step in EPSP is _____. Neurotransmitter opens ______ gated _______ channels
The first step in EPSP is GENERATION. Neurotransmitter opens LIGAND gated IONOTROPIC channels
In the second step of EPSPs, EPSPs propagate along the ______ region membranes towards the ______ _____
In the second step of EPSPs, EPSPs propagate along the INPUT region membranes towards the TRIGGER ZONE
In the third step of EPSPs, many EPSPs must ______ to drive the membrane potential to _______
In the third step of EPSPs, many EPSPs must SUMMATE to drive the membrane potential to THRESHOLD
In the fourth step of EPSPs, EPSPs must be coordinated in ______ and _____ in order to summate
In the fourth step of EPSPs, EPSPs must be coordinated in SPACE and TIME in order to summate
What type of neurotransmitter is predominate in the CNS?
Glutemate
What are ligand gated ionotropic channels?
Transmembrane proteins in the postsynaptic membrane
What two roles do the ligand gated ionotropic channels carry out?
- Bind to the neurotransmitter
- Open ion channels in receptor protein
What happens after the vesicle releases neurotransmitter into the synaptic cleft?
Neurotransmitter binds to receptors which opens channels for Na+ to fall through (depolarization)
Where are voltage gated channels located in a neuron?
Conductive region
NOT the cell body/dendrites
Where are ligand gated channels located in a neuron?
Input region/dendrite
What is membrane resistance (Rm)
Resistance of the movement of ions across a membrane
How does fewer leak channels affect Rm?
Increases/higher Rm
How does many leak channels affect Rm?
Decreases/lowers Rm
Why does having more leak channels lower membrane resistance?
All the positive charge exiting through leak channels leaves the membrane flimsy
