Midazolam Flashcards
1
Q
Presentation of Midazolam
A
5mg in 1ml amp
15mg in 3ml amp
2
Q
Pharmacology of Midazolam
A
Short acting CNS depressant
3
Q
Pharmacology of Midazolam (actions)
A
- anxiolytic
- sedative
- anti-convulsant
4
Q
Metabolism of Midazolam
A
In the liver - excreted by the kidneys
5
Q
Midazolam Indications
A
- Seizures - continuous/recurrent
- Convulsions associated with Lignocaine toxicity
- Sedation in the aggitated pt
- Sedation in psychostimulant OD
- RSI
- Sedation to enable intubation
- Sedation to maintain intubation
- Sedation to enable synchronised cardioversion
6
Q
Midazolam Contraindications
A
Known hypersensitivity to benzodiazepines
7
Q
Midazolam Precautions
A
- Pts with myasthenia gravis
- Can cause severe respiratory depression in pts with COPD
- CNS depressant effects of benzo’s are enhanced in the presence of narcotics and other tranquillisers including alcohol
- Reduced doses may be required for the elderly, pts with chronic renal failure, CCF or shock
8
Q
Route of Administration of Midazolam
A
IM
IV
9
Q
Side Effects of Midazolam
A
- Loss of airway control
- Respiratory depression
- Hypotension
- Depressed level of consciousness
10
Q
Effects of Midazolam
A
IM
Onset: 3-5min
Peak: 15min
Duration: 30min
IV
Onset: 1-3min
Peak: 10min
Duration: 20min
