UW 4-13-17

Question 1

What drug can reverse both the CNS and peripheral symptoms of severe atropine toxicity?

Answer 1

Physostigmine; neostigmine and edrophonium are quaternary structures and cannot cross BBB

Question 2

What part of the CNS does leptin act on?

Answer 2

Arcuate nucleus

Question 3

What are the actions of leptin?

Answer 3

Decreases NPY (decreasing appetite) and stimulates alpha-MSH (increasing satiety)

Question 4

What type of response is seen in administration of the liver attenuated oral poliovirus vaccine?

Answer 4

More robust oropharyngeal and intestinal mucosal IgA response

Question 5

What polio vaccine with produce a stronger mucosal secretory IgA immune response?

Answer 5

Live attenuated oral (Sabin)

Question 6

What does the 4th aortic arch give rise to?

Answer 6

On left, the aortic arch; on right, proximal R subclavian artery

Question 7

What does the 6th aortic arch give rise to?

Answer 7

Proximal pulmonary arteries; on left gives rise to ductus arteriosus

Question 8

What is the vascular derivative of the first aortic arch?

Answer 8

Maxillary artery

Question 9

What aortic arch does the common carotid artery come from?

Answer 9

Third

Question 10

What aortic arch does the hyoid artery arise from?

Answer 10

Second

Question 11

What vascular derivatives does the second aortic arch give rise to?

Answer 11

Stapedial artery; hyoid artery

Question 12

What is the role of ATP in skeletal and cardiac muscle contraction?

Answer 12

Release myosin head from its actin binding site; energize conformational change that resets the myosin head to contract again the next time it binds to actin

Question 13

What do the trocar and cannula pierce in a suprapubic cystostomy?

Answer 13

Layers of abdominal wall but will not enter the peritoneum (bladder is extraperitoneal)