Uworld 4/15

Question 1

Increased levels of what are detected on amniocentesis of neural tube defects?

Answer 1

AFP and AChE

Question 2

Colon cancers that result in IDA are more likely to be seen where in the colon?

Answer 2

Right side (ascending colon)

Question 3

Colon cancers that present with obstructing symptoms are usually found where in the colon?

Answer 3

Left sided lesions

Question 4

What type of antiarrhythmic is dofetilide?

Answer 4

Class III - blocks Potassium channels

Question 5

Anterograde axonal transport is mediated by what motor protein?

Answer 5

Kinesin

Question 6

Retrograde axonal transport is due to what motor protein?

Answer 6

Dynein

Question 7

What process is defective in xeroderma pigmentosum?

Answer 7

Nucleotide excision repair

Question 8

What is the inheritance pattern of xeroderma pigmentosum?

Answer 8

Autosomal recessive

Question 9

What is the function of the splicesome?

Answer 9

Removes introns from pre-mRNA during processing within the nucleus

Question 10

Spinal muscular atrophy is a disorder caused by a mutation in what gene?

Answer 10

SMN1

Question 11

A mutation in SMN1 in spinal muscle atrophy results in what?

Answer 11

Impaired assembly of snRNPs in LMNs

Question 12

What neurotransmitter is produced in the locus ceruleus?

Answer 12

Norepinephrine

Question 13

Where in the brainstem is the locus ceruleus located?

Answer 13

Posterior rostral pons near the lateral floor of the 4th ventricle

Question 14

Anti-Smith antibodies are directed against what?

Answer 14

SnRNPs (important part of splicesome)

Question 15

Injury to Meyer’s loop results in what type of visual deficit?

Answer 15

Contralateral superior quadrantanopia

Question 16

What is the mechanism of ANP and BNP?

Answer 16

Bind ANP receptors which are linked to guanylyl cyclase, resulting in increased cGMP and therefore vasodilation

Question 17

In what time frame do free wall ruptures occur post MI?

Answer 17

5-14 days

Question 18

What is pulsus paradoxus?

Answer 18

Exaggerated drop (>10 mmHg) in systolic blood pressure during inspiration

Question 19

In AAT deficiency, what is seen histologically?

Answer 19

Reddish-pink, PAS + granules of unsecreted, polymerized AAT in the periportal hepatocytes

Question 20

Patient started on isoniazid and B6 a month ago is now presenting with fever, anorexia and nausea, what is the most likely cause of these symptoms?

Answer 20

Hepatotoxicity

Question 21

What is the MOA of rasburicase?

Answer 21

Recombinant urate oxidase; catalyzes conversion of uric acid to allantoin (more soluble than uric acid)

Question 22

What is the function of the Nef gene in HIV?

Answer 22

Decreases expression of MHC class I

Question 23

What does biopsy show in polyarteritis nodosa show?

Answer 23

Segmental, transmural inflammation with fibrinoid necrosis