Immunology

Question 1

Auto Inflammatory dz associated with mutation in mevalonate kinase gene chromosome 12q24

Answer 1

Hyper immunoglobulin D syndrome - drink the melon

Question 2

Most cases of alloimmune neonatal neutropenia are mediated by antibodies that bind to human neutrophil antigen x

Answer 2

HNA-1a

Question 3

By 30 weeks gestation the x is the exclusive site for B cell maturation

Answer 3

Bone marrow

Question 4

Defects in the recombination activating gene x result in failure of T cell receptor generation

Answer 4

RAG1 or 2

Question 5

The most common thoracic duct anatomy involves how many ducts

Answer 5

One

Question 6

Only site you have hematopoetic stem cells post birth is

Answer 6

Bone marrow

Question 7

Initial event in pathogenesis of congenital heart block due to lupus is

Answer 7

Cardiocyte apoptosis

Question 8

Molecule most involved in trans endothelial migration of neutrophils is

Answer 8

Platelet endothelial cell adhesion molecule

Question 9

Margination of neutrophils is the most likely mechanism for neutropenia caused by

Answer 9

Drugs

Question 10

B cells from Where (within spleen or lymph nodes) give adaptive immune response against thymus dependent anitgens ?

Answer 10

Follicular

Question 11

Do infants younger than 31 weeks have less antibody titers to pertussis vaccine compared to term babies ?

Answer 11

Yes

Question 12

What medicine increases neutrophil chemotaxis in neonates ?

Answer 12

G CSF