Antitrematodal Drugs Flashcards
Liver fluke dz (fasciolosis)
Caused by flat worm: Fasciola hepatica (common or sheep liver fluke)
Most common and econ important dz by trematode parasites in farm animals
Nitroxynil uses
Adult stages of F. hepatica (8w post infection)
Ivermectin and BZD resistant H. contortus in sheep
Nitroxynil safety and toxicity
Well tolerated
Hyperthermia and hyperapnea with overdose (lethaL)
Stains wool
The slaughter clearance time of Nitroxynil is …
60 days
Salicylanilides
Closantel, rafoxanide, oxyclozanide
Closantel uses
Adult stages of F. hepatica (cattle, sheep, goat)
Alt. drug for resistant H. corntotus in sheep, adult nematodes and ectoparasites
Closantel effects
Labored breathing, weakness, ↓ vision
Forbidden in milk production
Slaughter clearance 28 dys
Benzenesulphonamides (Clorsulon) MOA
Inhibits tremanodes enzyme system for energy production
Safe, high TI
Clorsulon (SC or oral) uses
F. hepatica (SC + ivermectin)
Adult flukes >6w
Nematodes in cattle
Triclabendazole (TCBZ) MOA
Alternative binding site on tubulin molecule
Halogenated BZD
Triclabendazole PK
Flukicidal, highly protein bound, long t1/2
TCBZ uses
All stages of F. hepatica (acute and chronic) cattle, sheep and goats
Slaughter clearance: 56d
When shouldnt TCBZ be used?
Lactating animals or pregnant animals producing milk for human consumption
Phenoxyalkanes (Diamphenethide) uses
Acute fasciolosis of sheep (immature)
Effective from 1d-6w
Albendazole
Interferes with energy metabolism of the worm (some nematodes)
