PARACETAMOL OD Flashcards

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1
Q

what does the recommended therapeutic dose of paracetamol depend on?

A

ADULTS = max dose in 24 hrs is 4 grams

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2
Q

What is an ACUTE paracetamol overdose?

A

EXCESSIVE INGESTION over a period of less than one hour in the context of self harm

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3
Q

What is STAGGERED paracetamol overdose

A

Excessive ingestion over more than one hour in the context of TREATING PAIN (therapeutic overdose)
- this can also occur with the intent of self-harm

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4
Q

What is the typical presentation of therapeutic paracetamol excess

A
  • most pts are asymptomatic or only have mild GI symptoms at initial presentation
  • Untreated excess ingestion may cause varying degrees of liver injury
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5
Q

What are the common signs of excess within the first 24 hours ?

A
  • nausea and vomiting
  • general abdominal pain
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6
Q

What are the signs of ACUTE liver injury

A
  • abdominal pain
  • jaundice - sign of acute liver injury
  • hepatomegaly (enlargement of liver)
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7
Q

What are the high risk groups for a glutathione deficiency?(4)

A

these patients are at a higher risk of liver injury, secondary to paracetamol excess.
Patients at risk include:
- Malnourishment (eating disorder)
- Psychiatric disorders
- chronic disease (HIV, Cystic fibrosis, liver disease)
- alcohol-use disorder

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8
Q

What is the REVERSIBLE DRUG called for a paracetamol overdose?

A

ACETYLCYSTEINE

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9
Q
A
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