Rheumatic fever Flashcards
Does rheumatic fever generally affect young or old people?
Young
true or false: Rheumatic fever is common in the UK
False, almost exclusively in developing countries only
Rheumatic fever is a systemic response to what kind of bacteria?
B haemolytic group A strep
Give an example of a B haemolytic group A strep that cause rheumatic fever post infection
Strep. pyogenes (typically pharyngitis)
Approximately how many cases of rheumatic fever affect heart and cause rheumatic heart disease?
50%
In rheumatic heart disease, affected valves show what histologically?
Aschoff bodies
In rheumatic heart disease, antibodies against the M protein “c_____” resulting in auto-antibody mediated destruction and inflammation
crosslink
Which protein from S pyogenes reaches the heart valve tissues in rheumatic heart disease?
M protein
Which valve is most commonly affected in rheumatic heart disease?
Mitral valve
Rheumatic heart disease typically causes t____ leaflets of the mitral valve. This is called ____ ______
thickened
mitral stenosis
What are symptoms of rheumatic fever?
New murmur (especially mitral stenosis)
Sydenham’s chorea (uncoordinated jerky movements)
Arthritis
Erythema nodosum (tender red bumps symmetrically on shins)
Pyrexia
Evidence of strep A infection
How is Rheumatic heart disease diagnosed?
CXR shows cardiomegaly or heart failure/ mitral stenosis signs
ECHO to show extent of valvular damage
What criteria is used to diagnose Rheumatic fever?
Jones critiera
How is the Jones criteria used to diagnose rheumatic fever?
Recent symptoms of pyogenes infection + either 2 major or 1 major and 2 minor symptoms
Name some major symptoms of rheumatic fever on the Jones criteria
New murmur
Arthritis
Erythema nodosum
Sydenham’s chorea
