Lecture 13 Part 5 - MC

Question 1

What is the main function of PCSK9 in lipid metabolism?

A) It synthesizes LDL cholesterol in the liver.
B) It binds the LDL receptor, leading to its degradation.
C) It increases the synthesis of bile acids.
D) It transports cholesterol directly to peripheral tissues.

Answer 1

B

Question 2

How does PCSK9 influence LDL cholesterol levels in the bloodstream?

A) By increasing LDL production in the liver.
B) By decreasing the breakdown of LDL cholesterol.
C) By preventing the LDL receptors from removing LDL from the blood.
D) By converting LDL into HDL.

Answer 2

C

Question 3

What therapeutic strategy is considered for PCSK9 to lower LDL cholesterol levels?

A) Inhibiting PCSK9 to increase LDL receptor availability on hepatocytes.
B) Activating PCSK9 to decrease cholesterol synthesis.
C) Binding PCSK9 to increase its activity and enhance LDL degradation.
D) Removing PCSK9 from the liver to increase bile production.

Answer 3

A

Question 4

What triggers the release of PCSK9 from the liver?

A) A low level of cholesterol in the liver.
B) A high level of cholesterol in the liver.
C) A decrease in bile acids in the liver.
D) An increase in fatty acids in the blood.

Answer 4

B

Question 5

What is the potential effect of a drug that binds to PCSK9 in the bloodstream?

A) It would increase the amount of LDL cholesterol in the circulation.
B) It would decrease the breakdown of LDL receptors by the liver.
C) It would reduce the amount of LDL cholesterol in the circulation by increasing its uptake in the liver.
D) It would decrease the overall cholesterol levels in the body by enhancing bile production.

Answer 5

C