Rabbit Medicine, Pt. 2 Flashcards

1
Q

What is normal to seen in the GIT of rabbits on radiographs?

A
  • food within stomach and lower GI
  • gas dispersed throughout
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2
Q

Normal abdominal radiograph, rabbit:

A
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3
Q

What is the normal anatomy of the rabbit liver? What makes up a majority of its mass?

A

2 major lobes –> left and right both subdivided into lateral and medial lobes with quadrate and caudate lobes on the right (caudate prone to torsion

gut-associated lymphoid tissue (spleen is small)

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4
Q

What is always an abnormal finding when auscultating rabbit hearts? What can mimick a murmur?

A

arrhythmias

respirations

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5
Q

What are some causes of increased and decreased lung sounds in rabbits?

A

INCREASED - edema, pneumonia

DECREASED - pulmonary consolidation, intrathoracic fluid or mass

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6
Q

How do rabbits breath? What is a normal finding on bronchial endoscopy? What is normal finding on BAL cytology/microbiology?

A

obligate nasal breathers –> mouth breathing is a poor prognostic sign

severe hyperemia

higher amounts of macrophages

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7
Q

What are 3 normal parts of the normal anatomy of rabbit lungs?

A
  1. 3 left lung lobes - cranial, middle, caudal
  2. 4 right lung lobes - cranial, middle, caudal, accessory
  3. no connective tissue septa - pneumonia is ALWAYS lobar
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8
Q

What is the soft palate of rabbits like? What is their normal respiratory rate?

A

long, overlies epiglotting –> flips up when neck is hyperextended

30-60 bpm –> >200 with stress or hyperthemia

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9
Q

What is indicative of severe respiratory compromise in rabbits? What is a less significant finding?

A

open-mouthed breathing + nostril flaring

diaphragmatic breathing - thoracic wall excursions normal

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10
Q

What are common abnormalities seen in the upper respiratory system of rabbits?

A

nasal d/c or swelling - infection, neoplasia, FB (hay)

dermatitis - treponemiasis (rabbit syphilis, check perineum)

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11
Q

How is the CVS of rabbits evaluated? What are some normal findings?

A

doppler-echo

  • relatively small heart
  • left cranial vena cava and coronary veins terminate in coronary sinus
  • limited collateral coronary circulation
  • right AV valve has 2 cusps
  • arthersclerosis
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12
Q

What are 4 normal findings on abdominal examination of rabbits?

A
  1. unable to vomit
  2. stomach and cecum contain soft, compressible ingesta and minimal gas
  3. borborygmus auscultable
  4. fecal pellets palpable in colon
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13
Q

What are some abnormal findings on abdominal examination of rabbits?

A
  • difficult to palpate organs (obesity)
  • dry, doughy ingesta (ileus, cecal impaction)
  • tympany (obstruction)
  • hypermobility, diarrhea (enteritis)
  • painful cranial palpation (liver lobe torsion)
  • uterine pathology
  • thick compressible bladder (calcium sludge)
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14
Q

What are some abdnormal soft tissue/integumentary findings in rabbits?

A
  • focal alopecia and superficial crusting - mites, sebaceous adenitis
  • swellings/masses - abscesses, neoplasia, Cuterebra larvae
  • wounds
  • maggot infestation
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15
Q

What is commonly secondary to uterine disease in rabbits?

A

mammary gland hyperplasia and milk production

(primary neoplasia, like adenocarcinoma, not as common as in uterus)

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16
Q

What is found adjacent to genitalia in rabbits? What are some rectal/perineal abnormalities?

A

paired scent glands

  • urine scald
  • papillomatous rectal polyps
  • fecal or cecotroph matting
  • maggots
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17
Q

What is normal kidney structure in rabbits? What are 2 unique aspects to their urine?

A

unipapillate - 1 papilla, 1 calyx enter ureter

  1. fractional excretion of calcium is 45-60% - prolonged high Ca intake can result in aortic and renal mineralization
  2. biological or plant pigments excreted normally in urine - give a yellow to red color
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18
Q

What is the normal color or rabbit urine? What are 2 abnormal findings?

A

cloudy orange or reddish due to porphyrin (heme breakdown), will be homogenous

  1. blood - heterogenous clots or streaking
  2. calciuria - sludge
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19
Q

What is the normal anatomy of the rabbit uterus? What kind of ovulators are they? What is fetal resorption related to?

A

lacks a uterine body, has 2 uterine horns and 2 services

induced ovulators

dominance - common in subordinate does

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20
Q

What is normal gestation and litter size in rabbits? What is weaning like?

A

30-33 days - does pull fur to make nest a few days before parturition

4-24 altricial kits

does nurse kits once or twice daily and they begin to wean at 4-6 weeks

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21
Q

What should be done prior to OVH surgery in rabbits? What are 2 options for performing this surgery?

A

empty bladder to avoid contamination of peritoneal cavity

  1. ligate each uterine horn separately if removing cranial to cervix
  2. ligate at dorsal vagina if removing caudal to services
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22
Q

What are 2 normal findings when performing an OVH in rabbits?

A
  1. small ovaries
  2. mesometrium is highly vascular and primary site of fat storage
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23
Q

When do male rabbits go through puberty? When do their testicles descend?

A

6-10 months

3 months –> inguinal rings remain open, which allows testicles to retract into abdomen with fear, stress, or cold temperatures

(testicular lesions not common, usually neuter for behavioral reasons, like urine marking)

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24
Q

What kind of castration is required for male rabbits? How is the surgery site closed?

A

closed castration –> open inguinal rings

bury sutures in SQ and used tissue glue on skin

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25
Q

What is a common neurological finding in rabbits? What are some signs?

A

vestibulitis

  • nystagmus
  • head tilt
  • rolling (evaluate cornea)
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26
Q

What is the preferred site of blood collection in rabbits? What are 4 other options? How should systems be set up?

A

lateral saphenous - sternal or lateral recumbency, more proximal

  1. marginal ear veins - hold off a long time, hematoma common
  2. ventral ear artery (suboptimal)
  3. jugular vein
  4. cephalic vein

blood clots readily - flush with heparin and use a butterfly catheter

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27
Q

What are 2 options for urine collection in rabbits?

A
  1. manual expression
  2. cystocentesis - avoids iatrogenic rupture
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28
Q

Where are IM injections given in rabbits?

A

lumbar musculature (epaxials) and quadriceps

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29
Q

What is a normal finding in blood smears of rabbits? What is the normal lifespan of RBCs?

A

marked anisocytosis, higher reticulocyte numbers in younger rabbits

60-70 days

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30
Q

What are the 3 most common leukocytes seen in rabbit samples?

A
  1. heterophils (no neutrophils!)
  2. lymphocytes in younger rabbits
  3. pseudoeosinophils - small granules

(heterophils and lymphocytes equal >13 months)

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31
Q

What is the primary infection-fighting WBC in rabbits? What is most commonly seen with infections?

A

heterophils - does not contain lysozymes to liquefy purulent material

leukocytosis rare - heterophils > lymphocytes (also seen with stress due to cortisol release)

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32
Q

What are platelet counts in rabbits like?

A

higher compared to dogs and cats

  • > 800000 can indicate reactive thrombocytosis in response to inflammation or hemorrhage
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33
Q

Why is total protein counts for rabbits not commonly accurate in rabbits? ALT? What kidney values are evaluated?

A

analyzers use dye-binding assays with bromocresol green (BCG), which has poor affinity for rabbit serum proteins –> should use serum electrophoresis or assays validated for rabbit blood

not liver-specific –> associated

BUN, creatinine

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34
Q

What is best to submit for abscess cultures in rabbits?

A

wall > contents

submit for both aerobic and anaerobic cultures

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35
Q

What vein is avoided for injections?

A

ear veins –> thrombosis common

(use cephalic or saphenous)

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36
Q

What are some options for placing IV catheters in rabbits?

A

cephalic, saphenous, or mammary veins with 22-24 g catheter

  • weigh benefits with cost of stress
37
Q

What bone is used for IO catheters in rabbits? What equipment is used?

A

proximal femur greater trochanter

  • 20-22 g spinal needle (1-1.5 in)
  • anesthetize unless patient is critical
38
Q

What kind of medications must be used for oral administration?

A
  • commercially available or compounded liquids via dosing syringe through diastema
  • crush tablets in veggie baby food, mashed banana, or flavored enteral drink

CANNOT PILL

39
Q

What is the daily fluid requirements for rabbits? How is it given IV/IO? SQ?

A

100-120 mL/kg

fluid pump or small-volume infusion set

in 8 hour intervals

40
Q

How should rabbits be housed in hospitals?

A
  • same cages as for cats and dogs, but housed away from predator species*
  • quiet wards
  • litter box without kitty litter
  • allow a hide area
  • water bottle or bowl
41
Q

Why is it not recommened to place E-collars on rabbits?

A

will likely not eat well and will be unable to eat cecotrophs

(maximize fiber with feedings)

42
Q

What are some indications for parenteral feeding in rabbits? What is important to note about this method of feeding?

A
  • oral or GI lesions preclude enteral feeding
  • anorexic rabbit resisting syringe feeding

does not feed enterocytes or stimulate motility –> dextrose, lipids, amino acids

43
Q

What is a good option for sedation in rabbits?

A

quiet, calm environment + Midazolam +/- opioid

44
Q

How should rabbits be fasted before surgery? What induction is used?

A

fast for several hours - cannot vomit, but ensures the stomach is not entirely full

IM butorphanol + Midazolam

45
Q

What anticholinergic is used in rabbits?

A

glycopyrrolate –> rabbits produce atropinase

46
Q

What IV fluid rate is used in rabbits during surgery? How are they monitored?

A

10 mL/kg/hr

  • pulse ox
  • doppler
  • water-circulating heating pad, convective heater
47
Q

Why should rabbits be carefully shaved? What scrub is preferred?

A

thin skin

chlorhexidine scrub - less irritating than povidone-iodine

48
Q

What are some post-op needs for rabbits?

A
  • quiet, calm environment
  • analgesia - Buprenorphine, Butorphanol, Oxymorphone, Meloxicam
  • thermoregulation - incubator
  • nutritional support
49
Q

Are there vaccines approved for use in rabbits in the US? When are females recommended to be spayed?

A

no –> Europe and Australia have annual vaccines for Myxomatosis and Calicivirus (rabbit hemorrhagic disease)

before 2 y/o to prevent uterine neoplasia

50
Q

What are 3 common GI diseases seen in rabbits? What are signs of each? What causes each?

A
  1. enteritis complex - soft stool, diarrhea, enterotoxemia, death - stress, diet, antibiotics
  2. enterotoxemia - commonly seen in 3-6 weeks old - Clostridium spiroforme
  3. mucoid enteritis - commonly seen in 7-14 weeks old, anorexia, lethargy, weight loss, diarrhea, impaction - unknown, bacterial dysbiosis, hyperacidity of cecum
51
Q

What are 7 antibiotics that can lead to dysbiosis in rabbits? What drugs are preferred?

A
  1. Clindamycin
  2. Lincomycin
  3. Ampicillin
  4. Amoxicillin (+/- clavulanic acid)
  5. Cephalosporins
  6. oral penicillins
  7. Erythromycin

Fluoroquinolones, Sulfas, Chloramphenicol, Azithromycin, Metronidazole, injectable Penicillin

52
Q

What 3 treatments are recommended for enteritis in rabbits?

A
  1. aggressive supportive care
  2. Chloestyramine - binds bacterial toins associated with Clindamycin-induced
  3. Metronidazole
53
Q

What are 4 options for preventing enteritis in rabbits?

A
  1. high fiber diet
  2. avoid sudden diet changes
  3. make hay available to weanling rabbits (3 weeks)
  4. avoid early/forced weaning
54
Q

What are the 3 main causes bacterial enteritis in rabbits? Some additional?

A
  1. enteropathologenic E. coli - treated with TMS or Enrofloxacin until C/S results are obtained
  2. Lawsonia intracellularis - proliferative enteritis, acute diarrhea for 2-4 months
  3. Clostridium piliforme - Tyzzer’s disease, watery diarrhea in weanlings

Salmonella, Pseudomonas

55
Q

What are the 3 most common causes of viral GI disease in rabbits?

A
  1. Papillomatosis - oral growths in lab rabbits
  2. Coronavirus - diarrhea in lab rabbits, common in 3-10 weeks
  3. Rotavirus - high morbidity/variable mortality, villous atrophy at ileum
56
Q

How does rabbit hemorrhagic disease virus cause death? Where has this disease been seen?

A

causes hepatic necrosis and death from DIC in >2 months old rabbits

  • domestic rabbits, wild cottontails, jackrabbits, hares (US RHDV2)
  • endemic in Europe, Cuba, Australia, NZ
  • outbreaks in Middle East, South America, US
57
Q

How can the RHDV vaccine be obtained?

A

coordinate through state vet and USDA, only allowed in states where cases have been reported

  • commonly delayed and cost prohibited for shelters
  • Eravac, Filavac, US development through Medgene Labs
  • onset of immunity 1 week post vax with annual booster
58
Q

What is the most common parasite seen in rabbits? What are 2 types?

A

coccidia

  1. HEPATIC - E. stiedae, decreased hepatic function, bile duct obstruction
  2. INTESTINAL - E. perforans, subclinical common, signs associated with poor husbandry and overcrowding
59
Q

What are 3 other common parasites seen in rabbits? What are some non-pathogenic ones found?

A
  1. Cryptosporidia - C. parvum, diarrhea in young rabbits, peaking at 30-40 days
  2. nematodes - Passalurus ambiguus (pinworm)
  3. cestodes - Cittotaenia variabilis
  • Giardia duodenalis
  • Entamoeba cuniculi
  • Monoceroceomas cuniculi
  • Retortamonas cunicili
60
Q

What are the 4 most common cause of respiratory disease in rabbits?

A
  1. Pasteurella multocida - rhinitis, sinusitis, conjunctivitis, nasolacrimal infection, otitis, tracheaitis, pneumonia, abscesses
  2. Bordetella bronchiseptica - common inhabitant, prevalence increases with age
  3. Psuedomonas spp
  4. Staphylococcus spp
61
Q

What has been isolated in rabbits with respiratory signs housed close to rats?

A

Mycoplasma pulmonis

62
Q

What is a common cause of viral respiratory disease in rabbits? What is the most common etiology of fungal granulomas?

A

Myxoma virus –> nasal and ocular disease

injury

63
Q

What is the most common cause of neoplasia in female rabbits? What is the first sign? When is treatment recommended?

A

uterine adenocarcinoma - hematogenous metastasis within 1-2 years

hematuria or serosanguinous d/c

OVH if there are no signs of metastasis

64
Q

What can mimic uterine adenocarcinoma in rabbits?

A

endometrial hyperplasia or uterine polyps

65
Q

What are the 2 most common isolates from pyometra and endometritis in rabbits?

A
  1. P. multocida
  2. S. aureus
66
Q

In what 3 situations is pregnancy toxemia seen in rabbits? What are some signs?

A
  1. last week of gestation (nest building)
  2. obese rabbits
  3. inadequate caloric intake
  • weakness, depression
  • incoordination
  • coma
  • abortion
67
Q

What treatment is recommended for pregnancy toxemia? How can it be avoided?

A
  • supportive care
  • fluids + calcium
  • analgesia

avoid underfeeding and obesity during pregnancy and provide alfalfa

68
Q

What is indicative of pseudopregnancy in rabbits? What causes it?

A

hair pulling

corpus luteum secretes progesterone –> commonly resolved spontaneously, may involve hydrometra or pyometra

69
Q

What is a common cause of subclinical interstitial nephritis? What are common isolates of pyelonephritis?

A

Encephalitozoon cuniculi

P. multocida, Staphylococcus spp

70
Q

What are some noninfectious causes of renal disease in rabbits?

A
  • hypercalcemia
  • renal calcinosis
  • hypervitaminosis D
  • fatty degeneration from obesity
  • lymphosarcoma
71
Q

What are some medical causes of nephrotoxicity in rabbits? When does urinary bladder eversion commonly occur?

A
  • Gentamicin
  • Telazol (tiletamine)
  • Diclofenac

after kindling

72
Q

What are common isolated from abscesses in rabbits? How are they treated?

A
  • Staph
  • P. multocida
  • Pseudomonas
  • Proteus
  • Fusobacteria
  • Bacterioides
  • Actinomyces

surgical excision, antibiotics, PMMA beads –> common at tooth roots and retrobulbar

73
Q

What is moist dermatitis commonly secondary to? What are signs?

A

dental disease

  • wet dewlap
  • urine scald
74
Q

What causes ulcerative pododermatitis in rabbits?

A

clipping of hair on feet –> lack paw pads

75
Q

What are 2 causes of dermatophytosis in rabbits?

A
  1. Trichophyton mentagrophytes*
  2. Microsporum spp
76
Q

What are 4 common ectoparasites that affect rabbits? What treatment is avoided?

A
  1. Psoroptes cuniculi - ear mite
  2. Cheyletiella parasitovorax - fur mite (zoonotic)
  3. Leopracarus gibbus - fur mite (not zoonotic)
  4. Ctenocephalides felis/canis - fleas

Fipronil (Frontline) - GI signs, seizures –> can use Selamectin

77
Q

What are the most common causes of myiasis in rabbits?

A

Cuterebra and Wohlfahrtia vigil - maggots of dipterid flies

78
Q

What is the most common tick found in rabbits?

A

Haemaphysalis leporis-palustris

(continental rabbit tick)

79
Q

What dermatologic virus is commonly seen in rabbits? How is it transmitted? What acts as a reservoir? What signs are associated?

A

Myxomatosis (pox family)

arthropod bites

wild rabbits (Sylvilagus)

  • skin tumors in wild rabbits
  • lethargy, anorexia
  • fever
  • skin hemorrhage
  • high mortality
80
Q

What is the natural host of rabbit (shope) fibroma virus? How is it transmitted? What signs are seen?

A

Easter cottontail (Sylvilagus floridanus)

biting arthropods

wart-like tumors on face, feet, legs, and perineum

81
Q

What transmits rabbit (shope) papilloma virus? What signs are seen? How does it typically progress?

A

biting arthropods

keratinized lesions on ears, eyelids, neck, and shoulders

SCC (may spontaneously resolve)

82
Q

What causes Encephalitozoonosis? What are some signs? How is it diagnosed?

A

Encephalitozoon cuniculi - fungi

  • behavioral changes
  • head tilt
  • nystagmus
  • ataxia, rolling, seizures
  • renal pathology
  • phacouveitis
  • pneumonitis

indirect immunofluorescence, ELISA

83
Q

What does a positive result for Encephalitozoonosis indicate?

A

exposure, not cause of disease

repeat titers 3-4 weeks later + urine antibody analysis, CSF

84
Q

What treatment is recommended for Encephalitozoonosis? What are some side effects?

A

Benzimidazoles –> Oxibendazole, Fenbendazole, Albendazole

bone marrow suppression, death

85
Q

What are 6 common causes of neurologic disease in rabbits?

A
  1. cerebral larval migrans - Baylisascaris spp causes tremors, ataxia, circling, and vertical nystagmus (Oxibendazole)
  2. aberrant Cuterebra migrans
  3. Toxoplasmosis - uncommon, granulomatous meningoencephalitis
  4. otitis interna
  5. rabies
  6. herpes simplex virus
86
Q

What are signs of arthritis/DJD in rabbits? What is seen in radiographs?

A
  • abnormal gait
  • lameness
  • inability to hop
  • quiet, old, unkempt/messy

spondylosis, narrowed joint spaces, scoliosis

87
Q

What treatment is recommended for arthritis/DJD in rabbits? How should their enclosure be altered?

A

pain management - NSAIDs, Tramadol, Chondroitin, Glucosamine, Myristol, acupuncture, omega 3-FA

lower litterbox edge, proper hygiene

88
Q

What are some causes of vision loss in rabbits? What changes should be made when this occurs?

A
  • lenticular sclerosis
  • cataracts
  • glaucoma

keep a consistent schedule with food and water and cage changes, speak when approaching, provide a companion