ORPTH ADONS DSE of Skin Flashcards
- Canker sores is another name for
(a) Herpetic gingivostomatitis
(b) Shingles
(c) Recurrent aphthous stomatitis
(d) Chickenpox
(c) Recurrent aphthous stomatitis is one of the most common
oral mucosal pathoses. Allergies, genetic predisposition,
nutritional deficiencies, hematologic abnormalities,
hormonal influences, infectious agents, trauma, stress,
etc. have all been implicated as possible predisposing or
triggering factors. The mucosal destruction appears to
represent a T cell mediated immunologic reaction.
- The site where recurrent aphthous ulcer does not commonly
occur is
(a) Labial mucosa (b) Tongue
(c) Gingiva (d) Soft palate
(c) Ulcers of recurrent aphthous stomatitis occurs almost
exclusively on the nonkeratinized, movable mucosa of oral
cavity.
- Which of these oral structures is not affected in hereditary
ectodermal dysplasia?
(a) Enamel
(b) Bones
(c) Hair
(d) Sweat glands
(b) As the name suggests hereditary ectodermal dysplasia
represents a group of inherited conditions in which two
or more ectodermally derived anatomic structures fail to
develop. Thus bone being a mesodermal structure is not
affected.
- Which of the following statements regarding lichen planus is
incorrect?
(a) It is a T cell mediated autoimmune disease
(b) It is a B cell mediated autoimmune disease
(c) Wickham’s striae are seen within the lesions in oral cavity
(d) It is seen most commonly on buccal mucosa
(b) Lichen planus is a relatively common, chronic dermatologic disease that often affects the oral mucosa. Current
evidence indicates that this is an immunologically mediated
mucocutaneous disorder mediated by T lymphocytes
- Civatte or colloid bodies in lichen planus are derived from
(a) Degenerating basal cells
(b) Degenerating mast cells
(c) Degenerating fibroblasts
(d) Breakdown of RBCs
(a) Degenerating epithelial cells can be seen in the area of the
epithelium and connective tissue interface, i.e. basal layers
and have been termed colloid, cytoid, hyaline, or Civatte
bodies.
- One of the following lesions is not considered during the
differential diagnosis of lichen planus
(a) Erythema multiforme
(b) Leukoplakia
(c) Candidiasis
(d) White sponge nevus
(d) White sponge nevus is a relatively rare genodermatosis
(genetically determined skin disorder) that is inherited as an
autosomal dominant trait and manifests early in life. Other
lesions are caused by environmental factors like tobacco,
drug reaction, immunosuppression, etc.
- Auspitz’s sign and Monroe’s abscess are a component of which
of the following skin lesions?
(a) Erythema multiforme
(b) Lupus erythematosus
(c) Psoriasis
(d) Pemphigus
(c) Psoriasis is a skin disorder characterized by occurrence of
sharply demarcated dry papules covered by a delicate silvery
scales. If deep scales are removed, tiny bleeding points
are noticed (Auspitz’s sign). Munroe’s abscesses refer to
intraepithelial microabscesses.
- Stevens-Johnson syndrome is a severe form of
(a) Lupus erythematosus
(b) Erythema multiforme
(c) Pemphigoid
(d) Lichen planus
(b) Significant evidence points to the fact that psoriasis may be
an autoimmune disorder. Lesions of psoriasis are associated
with an increased T lymphocyte activity in the underlying
skin.
- Psoriasis is now believed to be a ________ disease.
(a) Viral
(b) Autoimmune
(c) Bacterial
(d) Mycotic
(b) A more severe form of erythema multiforme, StevensJohnson syndrome, is usually triggered by a drug rather than
infection. For such a diagnosis to be made, either the ocular
or genital mucosae should be affected in conjunction with
the oral and skin lesions.
- The virus implicated in triggering the immunological derangement
that produces erythema multiforme is
(a) Herpes simplex
(b) Human papilloma virus
(c) Herpes zoster
(d) Epstein-Barr
(a) Er ythema multiforme is a blistering, ulcerative
mucocutaneous condition of uncertain etiology. This is
probably an immunologically mediated process. In about
50 percent of the cases, the clinician can identify either a
preceding infection, such as herpes simplex or Mycoplasma
pneumoniae, or exposure to anyone of a variety of drugs,
particularly antibiotics or analgesics. These agents may
trigger the immunologic derangement that produces the
disease
- Skin lesions of pityriasis rosea clinically resemble
(a) Secondary syphilis
(b) Tertiary syphilis
(c) Primary syphilis
(d) Tuberculous ulcers
(a) Pityriasis rosea is a common benign papillosquamous
disease causing acute skin eruptions probably of viral
etiology, although no single virus is as yet implicated. The
clinical significance lies in the fact that the initial lesion
called “Herald spot” appears strikingly similar to that of
secondary syphilis and is manifested as bright red, 3–4 mm
sized ovoid lesion covered by a silvery scale.
- The disease, also known as Darier disease and characterized by
hyperkeratotic papules and various nail abnormalities is
(a) White sponge nevus
(b) Systemic lupus erythematosus
(c) Keratosis follicularis
(d) Incontinentia pigmenti
(c) Darier disease is characterized by numerous erythematous,
often pruritic, papules on the skin of the trunk and the scalp
that develop during the second decade of life. The palms
and soles often exhibit pits and keratoses. The nails show
abnormalities like longitudinal lines, ridges, or painful splits.
- Which one of these is not a genodermatosis?
(a) Keratosis follicularis
(b) Incontinentia pigmenti
(c) Dyskeratosis congenita
(d) Lichen planu
(d) Genodermatoses represent hereditary skin disorders
many of which are accompanied by various systemic
manifestations of different altered enzyme functions. Lichen
planus does not fall into this category, as it is classified as
an autoimmune disease.
- Which amongst the following skin diseases has a benign and a
malignant form?
(a) Lichen planus
(b) Acanthosis nigricans
(c) White sponge nevus
(d) Warty dyskeratoma
(b) Acanthosis nigricans is an acquired dermatologic disease
characterized by development of a velvety, brownish
alteration of the skin. In some instances, this unusual
condition develops in association with gastrointestinal cancer
and is termed malignant acanthosis nigricans. The cutaneous
lesion itself is benign, yet it is significant because it represents
a cutaneous marker for internal malignancy
- Nikolsky’s sign is positive in which of the following diseases?
(a) Cicatricial pemphigoid
(b) Bullous pemphigoid
(c) Pemphigus
(d) Bullous lichen planus
(c) Nikolsky’s sign refers to loss of epithelium due to rubbing
of apparently unaffected skin.