Integrity: Skin in Health and Disease Flashcards
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What are the dead skin cells called?
Corneocytes
What are dendritic cells in the epidermis called?
Langerhans cell
Where else are dendritic cells found?
Anywhere that the body has contact with the external world:
the inner lining of the nose, lungs, stomach and intestines
WHat is erythema?
Simply inflamatory redness of the skin
WHat is eythema in sunburn?
A response to DNA damage
How does the wavelength of light correlate with erythema and skin damage?
Where is melanin produced and stored?
In malanosomes
Malanosomes are lysosome like organelles, these actually produce the melonin. Made of the products involved in the production of malanin are toxic so they have to be stored in lysosome like parcels.
Malanosomes are made by the malaocytes but spread throughout the keratinocytes
Where are malanosome found in the basal cells?
As a sun hat on top of the nucleus
What has more of effect at UV protection.
Constituative pigmentation or aquired (facaltative) pigmentation?
Constituative
Two broad categories of skin cancers
Malanoma and non-melanoma
Example of a non-melanoma skin cancer
Basal cell carcinoma
What is more common basal cell carcinoma or malanoma?
Basal cell carcinoma
What has a worse prognosis malanoma or basal cell carcinoma?
Malanoma, malanomas often metastisise
WHat are the two types of melanin?
eumelanin: dark
pheomelanin: red
What happens to Thymine when it is exposed to UV radiation.
How is this repaired?
What is the name of the condition when this repair fails
It forms a thymine-dimer.
This is repaired by excision
Defects in excision repair occur in Xeroderma Pigmentosum
