16 - Musculoskeletal Neoplasia

Question 1

Primary bony neoplasia

Answer 1

Neoplasia arising directly from the bone

Question 2

Secondary bony neoplasia

Answer 2

Spread from an adjacent site

Question 3

Monostrotic

Answer 3

Lesion affecting a single bone

Question 4

Polystotic

Answer 4

Lesion affecting more than one bone

Question 5

Diagnostics of skeletal neoplasia

Answer 5

CBC, serum, urinalysis

Question 6

Cytology for neoplasia requires

Answer 6

Heavy sedation

Question 7

Best to sample cytology where

Answer 7

Closer to center of lesion

Question 8

Accuracy of cytology

Answer 8

70%

Question 9

Tools needed for biopsy

Answer 9

Jamshidi and Michele trephine

Question 10

Risk of biopsy

Answer 10

Pathological fracture, non diagnostic sample

Question 11

Accuracy of biopsy

Answer 11

80 - 90%

Question 12

Thoracic CT for lesion

Answer 12

1 mm

Question 13

Thoracic radiographs for lesion s

Answer 13

7 - 9 mm in size

Question 14

Most common primary bone neoplasma

Answer 14

Osteosarcoma

Question 15

Osteosarcoma primarily affects

Answer 15

Appendicular skeletal

Question 16

Two types of osteosarcoma

Answer 16

Endosteal, periosteal, parosteal

Question 17

Endostteal

Answer 17

Most common form arises from medullary cavity

Question 18

Periosteal

Answer 18

Can invade into medically cavity from periphery and cause bony lysis and reactive bone formation

Question 19

Parosteal

Answer 19

Arises from periosteum, forms an expansive mass that surrounds but does not invade cortical bone

Question 20

Least aggresive osteosarcoma

Answer 20

Parosteal

Question 21

Common locations of osteosarcoma

Answer 21

Distal radius, distal femur, proximal tibia, proximal humerus

Question 22

Radiograph of osteosarcoma

Answer 22

Cortical lysis, periosteal reaction, extension of osteogenesis into adjacent soft tissues, loss of trabecular pattern in metaphyseal bone

Question 23

Gross metastasis at time of initial presentation :

Answer 23

15%

Question 24

Where does osteosarcoma like to metastasis

Answer 24

Lungs , bones, lymph nodes

Question 25

Prognostic indicators of osteosarcoma

Answer 25

Age, body weight, metastasis?, elevated ALP

Question 26

Elevated ALP indicated of

Answer 26

Tumor burden if elevated within 40 day sof treatment

Question 27

Surgery of osteosarcoma

Answer 27

Amputation, fracture repair of pathological fracture, partial amputation

Question 28

Radiation therapy treatment for osteosarcoma

Answer 28

Stereotactic radio surgery, palpitations RT

Question 29

Stereotactic radio surgery

Answer 29

Single, large targeted dose of radiation

Question 30

Palliative RT

Answer 30

Reduces pain/inflammation to improve quality of life for dogs that cannot undergo amputation

Question 31

Chemotherapy often in conduct with

Answer 31

Amputation to increase survival time

Question 32

Chemotherapy drugs

Answer 32

Doxorubicin, Cisplatin

Question 33

Conservative managements

Answer 33

Analgesia and biphosphonates

Question 34

Ideal treatment

Answer 34

Amputation and chemo

Question 35

Bisphosphoates

Answer 35

Helps decrease bones resoprion

Question 36

Amputation ST

Answer 36

6 m

Question 37

Amputation w chemo ST

Answer 37

12 - 14 m

Question 38

RT alone ST

Answer 38

4 - 10 m

Question 39

Conservative management ST

Answer 39

2 - 3 m

Question 40

Osteosarcoma in cats of what age

Answer 40

8 - 10 year

Question 41

Treatment for cats with osteosarcoma

Answer 41

Amputation

Question 42

Second most commone appendicular neoplasma

Answer 42

Chondrosarcoma

Question 43

Chondrosarcoma lower

Answer 43

Metastatic rate

Question 44

Chondrosarcoma often found in what skeleton

Answer 44

Axial skeleton

Question 45

How do you treat chondosarcoma

Answer 45

Amputation treatment of choice

Question 46

Prognostic factors condorosarcoma

Answer 46

Better if skull or appendicular

Question 47

MST of Chondrosarcoma amputation

Answer 47

32 months

Question 48

Secondary bone neoplasia sites commonly affected

Answer 48

Humerus, femur and vertebrae

Question 49

Secondary bone neoplasia

Answer 49

Mammary, prostatic, pulmonary, hepatic, hemangiosarcoma, osteosarcoma

Question 50

Joint neoplasia common sites

Answer 50

Elbow and stifle

Question 51

Synovial cell sarcoma common sites

Answer 51

Elbow and stifle

Question 52

Synovial histocytic sarcoma common sites

Answer 52

Stifle - secondary to chronic inflammation

Question 53

Look alike neoplasia

Answer 53

Fungal ( blasto), Osteomyelitits, Bone cysts , RUIN

Question 54

Osteomyelitis characterized by

Answer 54

More evident region of demarcation between normal and abnormal bone

Question 55

Bone crust seen in

Answer 55

Younger dogs, uncommon, DX with bone biopsy

Question 56

RUIN

Answer 56

Radioulnar ischemic necrosis

Question 57

RUIN is

Answer 57

Permeating destruction of bone which extends to the interosseous ligament region to the radius and ulna