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Arthritis Flashcards

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1
Q

The articular cartilage starts out perpendicular or parallel

A

Longitudinal

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2
Q

What is the mark that separates for uncalcified and calcified

A

Tide mark

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3
Q

As cartilage is loaded what happens

A

Water is squeezed out until you reach equilibrium

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4
Q

In cartilage what is sucking all the water in

A

Aggrecan

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5
Q

Type 2 collagen is only found

A

Cartilage

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6
Q

Function of chondorcytes

A

Makes and breaks down new matrix

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7
Q

As cartilage is broken down, what is left

A

Keratin sulfate

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8
Q

Common clinical findings of arthritis

A

Lameness, joint effusion, stiffness, decreased activity, decreased joint range of motion and muscle atrophy

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9
Q

Non inflammatory joint disorders

A

Osteoarthritis , trauma, neoplasia

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10
Q

Inflammatory joint disease examples

A

Non infectious and infectious arthritis

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11
Q

2 categories of non infection inflammatory disease

A

Nonerosive and erosive

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12
Q

Lupus is an example of what joint disease

A

Nonerosive

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13
Q

rheumatoid is example of what joint disease

A

Erosive

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14
Q

What should u do before joint tap

A

Radiographs

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15
Q

What do you need for joint tap

A

21 g needle, 3 cc syringe, EDTA tube to collect serum

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16
Q

Describe the clarity of OA

A

Transparent

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17
Q

Describe the clarity of erosive immune mediated arthritis

A

Clear or opaque

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18
Q

Describe the clarity of bacterial

A

Opaque

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19
Q

Viscosity of OA

A

High

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20
Q

Viscosity of erosive immune mediated

A

Low

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21
Q

With osteoarthritis what changes occur

A

All aspects of joint organ

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22
Q

Where does the pain come from with OA

A

Synovitis

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23
Q

What is the first thing to happen with OA

A

Synovitis

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24
Q

Progressive degenerative changes result in

A

Decreased structure and function of cartilage and atrophy of articular tissues

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25
Example of normal forces acting on an abnormal joint
Secondary to a developmental condition - hip dysplasia or elbow dysplasia
26
Abnormal forces acting on a normal joint
Trauma - luxation or fracture
27
Clinical signs of OA
Joint pain, tenderness, limitation of movement, crepitus, joint effusion, degrees of inflammation
28
What is released during inflammation of OA
Destructive cellular enzymes
29
What are the effects of loosing Proteoglycans in OA
Softer cartilage which is easier to damage
30
Alteration of preoteoglycans content does what
Reduces stiffness
31
Do owners recognize mobility issues in their dogs
Probably not
32
Lupus is an example of what type of arthritis
Immune - non erosive
33
Poly arthritis is an example of what type of arthritis
Immune - non erosive
34
Idiopathic poly arthritis is an example of what type of arthritis
Immune - non erosive
35
Plasmacytic lymphocytic gonitis is an example of what type of arthritis
Immune - non erosive
36
Drug and vaccine induced arthritis is an example of what type of arthritis
Immune - non erosive
37
Gonitis
Stifle joint inflammation - boxers
38
What breed is associated with polyarthritis
Spaniel breeds
39
What is the most common form of inflammatory polyarthritis
Idiopathic polyarthritis
40
Anything that causes an antigen antibody reaction may cause
Polyarthritis
41
Type 1 idiopathic polyarthritis
Isolated condition
42
type 2 idiopathic polyarthritis
Associated with other infections
43
Type 3 idiopathic polyarthritis
Associated with GI disease
44
Type 4 idiopathic polyarthritis is associated with
Neoplasia of other sites
45
Chief complaint of idiopathic polyarthritis
Shifting leg lameness
46
Physical finding of idiopathic polyarthritis is primarily in
Distal joints
47
Synovial fluid analysis of idiopathic polyarthritis
Turbid, cloudy, low viscosity, water, elevated cell count,
48
What is found in cell content of idiopathic polyarthritis
Mature non toxic polymorphonuclear leukocytes, no bacteria
49
Potiental causes of idiopathic polyarthrisi
Ehrlichia, RMSF, lymes, heart worms, bacterial infections, drug history
50
First step therapy of idiopathic polyarthritis
Doxycycline
51
Second step of idiopathic polyarthritis
Steroid
52
Third step of therapy for idiopathic polyarthritis
Steroid + chemotherapy
53
Examples of immunosuppressive therapy for immune mediated joint disease
Pred, leflunomide, azathioprine, cyclosporine, cyclophosphamide
54
Examples of plasmacytic lymphocytic gonitis
Canine stifle joint, cranial drawer instability, severe Synovitis
55
What drug can contribute to drug induced arthritis
Sulfa
56
Examples of immune - erosive arthritis
Canine RA or late stages SLE
57
Canine Ra is due to
Altered IgG
58
Pathophysiology of RA
Antibody / antigen complexes are deposited in teh synovium, induce arthritis, leads to cartilage erosion, subchondral lysis, collapse and deformation of joints
59
Examples of bacterial infectious arthritis
Direct infection, hematogenous infection, spread from surrounding tissues
60
Synovial fluid for bacterial arthritis
Turbid, low viscosity, elevated cell count, toxic WBC, bacteria
61
Rickettsial disease
Lymes, RMSF, ehrlichia
62
Testing for Lymes
Western Blot test, C6 snap test
63
How do you treat Lyme disease
Tetracycline, doxycycline, minocycline, and amoxicillin, erythromycin

Musculoskeletal (17 decks)

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