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pharma > PROTEIN SYNTHESIS INHIBITORS > Flashcards

PROTEIN SYNTHESIS INHIBITORS Flashcards

1
Q

Doxycycline, Minocycline

A. TETRACYCLINES
B. GLYCYLCYCLINES
C. AMINOGLYCOSIDES
D. MACROLIDES

A

A

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2
Q

T/ F

dairy products, calcium, magnesium, & aluminum compounds, or sodium bicarbonate (antacid) impair tetracycline absorption

A

T

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3
Q

cross the placental barrier [2]

A. TETRACYCLINES
B. GLYCYLCYCLINES
C. AMINOGLYCOSIDES
D. MACROLIDES

A

TETRACYCLINES, AMINOGLYCOSIDES

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4
Q

localized aggressive periodontitis (A. actinomycetemcomitans

A. TETRACYCLINES
B. GLYCYLCYCLINES
C. AMINOGLYCOSIDES
D. MACROLIDES

A

A

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5
Q

inhibits clearance of Warfarin (anticoagulation must be monitored)

A. TETRACYCLINES
B. GLYCYLCYCLINES
C. AMINOGLYCOSIDES
D. MACROLIDES

A

B

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6
Q

Tigecycline

A. TETRACYCLINES
B. GLYCYLCYCLINES
C. AMINOGLYCOSIDES
D. MACROLIDES

A

B

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7
Q

Tobramycin, Amikacin, Gentamicin, Streptomycin

A. TETRACYCLINES
B. GLYCYLCYCLINES
C. AMINOGLYCOSIDES
D. MACROLIDES

A

C

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8
Q

synergize with beta-lactam antibiotics

USES
→ tularemia

A. TETRACYCLINES
B. GLYCYLCYCLINES
C. AMINOGLYCOSIDES
D. MACROLIDES

A

B

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9
Q

ototoxicity, nephrotoxicity
A. TETRACYCLINES
B. GLYCYLCYCLINES
C. AMINOGLYCOSIDES
D. MACROLIDES

A

C

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10
Q

Erythromycin, Clarithryomycin, Azithromycin, Telithromycin

A. TETRACYCLINES
B. GLYCYLCYCLINES
C. AMINOGLYCOSIDES
D. MACROLIDES

A

D

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11
Q

drug of choice for urogenital infections due to Chlamydia occurring during pregnancy

A. Erythromycin,
B. Clarithryomycin
C. Azithromycin
D. Telithromycin

A

A

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12
Q

can penetrate the cell wall
→ effective against oral spirochetes &
pigmented anaerobes

A. Erythromycin,
B. Clarithryomycin
C. Azithromycin
D. Telithromycin

A

C

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13
Q

preferred treatment in patients with urethritis due to C. trachomatis

A. Erythromycin,
B. Clarithryomycin
C. Azithromycin
D. Telithromycinj

A

C

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14
Q

against bacteria responsible for community-acquired respiratory tract infection

A. Erythromycin,
B. Clarithryomycin
C. Azithromycin
D. Telithromycinj

A

D

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15
Q

used with caution in patients with renal insufficiency

A

Telithromycin

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16
Q

use is restricted to life-threatening infections for which no alternative exists

A

CHLORAMPHENICOL

17
Q

excellent activity against anaerobe

A

CHLORAMPHENICOL

18
Q

gray baby syndrome

A. CHLORAMPHENICOL
B. CLINDAMYCIN
C. QUINUPRISTIN OR DALFOPRISTIN
D. LINEZOLID

A

A

19
Q

primarily in the treatment of infections caused by anaerobic bacteria such as Bacteroides fragilis, non-enterococcal Gram (+) cocci

A. CHLORAMPHENICOL
B. CLINDAMYCIN
C. QUINUPRISTIN OR DALFOPRISTIN
D. LINEZOLID

A

B

20
Q

ADVERSE EFFECTS
→ most serious is pseudomembranous colitis (overgrowth of C. difficile) which elaborates necrotizing toxins (treatment by Metronidazole or Vancomycin)

A. CHLORAMPHENICOL
B. CLINDAMYCIN
C. QUINUPRISTIN OR DALFOPRISTIN
D. LINEZOLID

A
21
Q

reserved for the treatment of Vancomycin-resistant Enterococcus faecium

A. CHLORAMPHENICOL
B. CLINDAMYCIN
C. QUINUPRISTIN OR DALFOPRISTIN
D. LINEZOLID

A

C

22
Q

bactericidal against Strep. and C. perfringens

A. CHLORAMPHENICOL
B. CLINDAMYCIN
C. QUINUPRISTIN OR DALFOPRISTIN
D. LINEZOLID

A

D

23
Q

effective in treatment of gonorrhea but not syphilis

A

FLUOROQUINOLONES

24
Q

exhibit concentration-dependent bacterial killing

A

FLUOROQUINOLONES

25
Q

drug of choice against anthrax

A. Ciprofloxacin
B. Norfloxacin
C. Levofloxacin
D. Moxifloxacin

A

A

26
Q

→ effective against both Gram (+) & Gram (-)
→ uncomplicated & complicated UTI, prostatitis

A. Ciprofloxacin
B. Norfloxacin
C. Levofloxacin
D. Moxifloxacin

A

B

27
Q

phototoxicity

A

FLUOROQUINOLONES

28
Q

CONTRAINDICATIONS
→ avoided in pregnant women, nursing mothers and children < 18 years old because in children it can cause articular cartilage erosion

A

FLUOROQUINOLONES

29
Q

→ bound to serum albumin

A

SULFONAMIDES

30
Q

ADVERSE EFFECTS
→ crystalluria
o risk of stone formation
→ hypersensitivity
o Stevens-Johnson syndrome

A

SULFONAMIDES

31
Q

20-50 fold more potent than sulfonamide

A

TRIMETHOPRIM

32
Q

narrow-spectrum

A

NITROFURANTOIN

pharma (15 decks)

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