1.8 Neurotransmitter Biochemistry: Acetylcholine and Serotonin (pg 291-306) Flashcards Preview

NMSK B Test 1 > 1.8 Neurotransmitter Biochemistry: Acetylcholine and Serotonin (pg 291-306) > Flashcards

Flashcards in 1.8 Neurotransmitter Biochemistry: Acetylcholine and Serotonin (pg 291-306) Deck (22):
1

What is the ionic receptor for Ach?

Cholinergic nicotinic

2

What is the metabotropic receptor for Ach?

Cholinergic muscarinic

3

What makes the Cholinergic nicotinic receptor different?

Are ion channels that contain five protein subunits that bind more tightly to nicotine than to muscarine

4

What makes the Cholinergic muscarinic different?

G-protein coupled receptors that contain a single protein that binds more tightly to muscarine than to nicotine

5

What is an Acetyl group?

Two carbon chemical group, attached through an ester bond

6

What is a Choline?

An amine containing compound that is often found in the liver

7

Where is Ach produced?

o Diagonal band of Broca, Medial septal nucleus, nucleus basalis, and pedunculopontine nucleus.

8

In the brain what is Ach responsible for?

Attention, memory

9

What actions is dopamine in charge of in the brain?

Reward, attention, decisions

10

Where is dopamine made?

Substantia nirgra

11

What is actions is serotonin mainly in charge of?

Homeostatis, sleep, wake, pain

12

What does serotonin do in the endothelial cells?

Regulates blood pressure

13

What does serotonin do in the intestines?

Regulates digestion

14

What molecule is serotonin derived from?

Tryptophan

15

What converts tryptophan to 5-hydroxytrptophan?

Tryptophan hydroxylase

16

What is another name for serotonin?

5-hydroxytrptophan

17

What does Tryptophan hydroxylase, phenylalanine hydroxylase, and tyrosine hydroxyls require for activation?

-molecular oxygen (O2) by iron and tetrahydrobiopterin
cofactors

18

What actions does Norepinephrine have in the brain?

Attention, response to stimuli

19

What does molecularly does acetylchonline esterase do?

Hydrolysis of an ester bond inserts the oxygen atom from the water to form a carboxylic

20

What is norepinephrine made?

Locus ceruleus, laterel tegmental system

21

What does choline acetytransferase do?

Binds to choline and to acetylcoenzyme A and transferse the actyl group from acetylcoenzyme-A to choline

22

What does a deficiency of choline cause?

Deficiency of choline interferes with lipid processing and leads to fat buildup in the liver (Nonalcoholic fatty liver disease = NAFLD)