19- Intro to Pharmacology of ANS (CIS) & DSA

Question 1

What are the neurotransmitters and receptors of the Parasympathetics?

Answer 1

Neurotransmitter – ACh

Receptors – nAChR; mAChR

Question 2

What are the neurotransmitters and receptors of the Sympathetics?

Answer 2

Neurotransmitter – NE; Epi; ACh

Receptors – alpha; beta; nAChR; mAChR

Question 3

This is the major NT of the parasympathetic nervous system. It comes from all preganglionic autonomic fibers and all postganglionic parasympathetic fibers.

Answer 3

ACh (cholinergic)

***Also comes from a few postganglionic sympathetic fibers (sweat glands)

Question 4

This is the major NT of the sympathetic nervous system. It comes from the vast majority of postganglionic sympathetic fibers.

Answer 4

NE (adrenergic)

Question 5

Synthesis of this only occurs in the Adrenal Medulla and in a few neuronal pathways in the brainstem.

Answer 5

Epinephrine (adrenergic)

Question 6

This is the NE and Epi precursor, and acts on the CNS and renal vascular smooth muscle.

Answer 6

Dopamine (dopaminergic)

Question 7

What type of receptors stimulate contraction of all smooth muscle?

Answer 7

Alpha1

Muscarinic

Question 8

What type of receptors stimulate relaxation of all smooth muscle?

Answer 8

Beta2

***Remember, Beta1 receptors are specific to the heart!