1.9b Cell-mediated Immunity

Question 1

Most antigens that stimulate cell-mediated immunity are (intracellular/extracellular) in nature?

Answer 1

Intracellular

Question 2

Antigen receptors react specifically to many antigens. (True or false)

Answer 2

False!

Question 2

Macrophages’ phagocytic ability is increased by (2)?

Answer 2

ingestion of antigenic material

cytokines

Question 3

Helper T cell is also known as

Answer 3

CD4+ cells

Question 3

Td cell is associated to what?

A. Planting of rice

B. Watering of plants

C. Plantsa-ing of clothes

D. Transplant rejection

Answer 3

Duh!! Ewan ko na lang kung mali ka pa dito. :)

Question 3

Are NK cells phagocytic?

Answer 3

No.

Question 3

Type of NK cell receptor that recognizes HLA-B or HLA-C molecules

Answer 3

KIRS

Question 4

Who has the greatest ability to make new T cell?

A. Ate Mariz

B. Ate Ecar

C. Doc Torres

D. Junibi

Answer 4

D. Junibaby :)

Question 4

Td cells are mostly what kind of Tcell?

Answer 4

Th cell

Question 4

Natural Killer Cells express antigen-specific receptors (True or False)

Answer 4

False!

Question 5

MHC I can be found in?

Answer 5

All nucleated cells of the body

Question 7

IL-1 is for?

IL-2 is for?

(role in cell-mediated immunity)

Answer 7

IL-1 = activation of Th cell

IL-2 = proliferation and differentiation into mature Th cell

Question 8

Main function of thymic factors.

Answer 8

For maturation and maintenance of T cell.

Question 8

Two types of surface receptors found in NK cells.

Answer 8

Lectin-like NK-cell receptors

Killer Ig-like receptors

Question 9

MHC II can be found where?

Answer 9

Macrophages and B cells

Question 11

Released by cytotoxic Tcell that is responsible for the formation of PORES in the membrane of the target foreign body.

Answer 11

Perforin

Question 11

Turned off when an antigen is no longer present.

Answer 11

Seppressor T cells ( Ts cells)

Question 12

Lytic activity of NK cells is enhanced by?

Answer 12

High levels of IFN-alpha and IFN-beta

Question 13

Mechanism by which Tcell+Ag receptors are stimulated to be differentiated into the effector Tcell that carry out cell-mediated immunity

Answer 13

Clonal Selection.

Question 16

What are responsible for secondary immune response?

Answer 16

Memory cells

Question 18

Plays an essential role in bacterial escape from phagosome into the cytoplasm where the pathogen multiplies more efficiently

Answer 18

CytoLLO

Question 20

These are large, granular lymphocytes mophologically related to T cell?

Answer 20

NK cells

Question 21

Cells which ingest and process the antigen then diplay fragments of the antigen on the cell surface

Answer 21

APCs

Question 22

Cell-mediated immunity is transferrable to fetus via placenta. (True/False)

Answer 22

False!!!

Question 23

Not well understood.

Answer 23

Life of a med student. :(

Question 24

Phagocytic cell that are usually found in the resting state

Answer 24

KRYSTEL!!! | (Macrophages)

Question 25

T cells migrate where after differentiation in the thymus gland?

Answer 25

Not in Texas. Not in Las Pinas. In lymphoid tissue!

Question 26

What is the key cellular component of cell-mediated immunity?

Answer 26

T-rex? T-test? T-cells!!!! :)

Question 28

Lectin-like NK-cell receptors bind to (carbs or proteins)?

Answer 28

proteins!

Question 29

When a Th cell receptor binds to the MHC-Ag complex, APC is stimulated to secrete what?

Answer 29

IL-1

Question 30

Cells for which cell-mediated immunity was originally named.

Answer 30

Delayed Hypersensitivity Cell (Td cell)

Question 32

Most important virulence determinant of L. monocytogenes.

Answer 32

CytoLLO

Question 33

Consists of cell-surface proteins unique to each individual and indicate self molecules

Answer 33

MHC

Question 34

Th : MHC class ? Cytotoxic Tcell : MHC class ?

Answer 34

Always remember: Helper Tcell : CD4: MHC class 2: 4 x 2 =8 Cytotoxic Tcell: CD8: MHC class 1: 8 x 1 = 8

Question 36

APCs are composed primarily of what? A. Apple B. Pineapple C. Citrus D. Answer the question!

Answer 36

Macrophages

Question 37

They attack large parasites.

Answer 37

NK cells

Question 38

Cell-med immunity can stimulate NK cells, macrophages, and other leukocytes to kill antibody-coated cells that are too large to be phagocytosed, in the presence of what?

Answer 38

Antibodies

Question 39

Type of CD4+ that is responsible for the up-regulation of humoral responses.

Answer 39

Th2 cell

Question 40

NK cells play a role in ADCC. What is ADCC?

Answer 40

Antibody-dependent cellular cytotoxicity

Question 41

Th1 is for what?

Answer 41

Up regulation of cellular responses (NK cell, Tcell, Bcell, and macrophage function)

Question 42

To maintain the effectiveness of cell-mediated immunity, it generally requires what?

Answer 42

Presence of Ag

Question 43

T cells develop from (what type of cell?) in the (what) and they mature (where? Clue: T-t-t-cell).

Answer 43

What type: stem cell in the what: bone marrow where: thymus gland