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DEN 7108 Micro and Immuno Concepts Part II > 2/7 Nguyen Other DNA Viruses > Flashcards

2/7 Nguyen Other DNA Viruses Flashcards

(64 cards)

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1
Q

Adenovirus family

A

Adenoviridae

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2
Q

Adenovirus structure

A
  • Naked
  • Icosahedral
  • dsDNA
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3
Q

What are the subgroups of Adenovirus?

A

A-F (A, B1, B2, C, D, E, F)

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4
Q

Each subgroup of Adenovirus has different _____

A

Tropisms

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5
Q

Adenovirus B1 tropism

A

Respiratory

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6
Q

Adenovirus B2 tropism

A

Renal

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7
Q

Adenovirus C tropism

A

Respiratory

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8
Q

Adenovirus D tropism

A

Ocular and other

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9
Q

Adenovirus E tropism

A

Respiratory

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10
Q

Adenovirus F tropism

A

Intestinal

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11
Q

Adenovirus capsule contains ____ which binds to ____ on host cell membranes to gain entry into the cell

A

Penton base; CAR (Coxsackiecirus and adenovirus receptor)

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12
Q

Adenovirus is a great _____

A

Vector for vaccines and gene therapy

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13
Q

Adenovirus was used as a vector in which well known vaccine?

A

Janssen (COVID) vaccine

contains DNA encoding spike protein

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14
Q

Adenovirus common clinical presentations

A
  • Respiratory
  • Conjunctivitis
  • Gastroenteritis
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15
Q

Adenovirus respiratory clinical presentation

A

Colds

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16
Q

Adenovirus ____ can cause conjunctivitis

A

Group D (ocular mucosa, highly contagious)

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17
Q

Adenovirus ____ can cause gastroenteritis/diarrhea

A

Group F (serotypes 40-42)

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18
Q

Adenovirus mode of spread

A

Person to person; coughing or sneezing (spreads like the common cold)

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19
Q

Adenovirus can produce severe complications in ____, such as ____

A

Immunocompromised patients; viremia

can spread to skin and multiple organs

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20
Q

Poxviridae contains what viruses?

A
  • Smallpox
  • Cowpox
  • Vaccinia
  • Monkeypox
  • Molluscum contagiosum
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21
Q

What are the two smallpox variants?

A
  • Variola major (more severe)
  • Variola minor (less severe)
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22
Q

Of the two smallpox variants, ____ is more severe and has a 30-50% mortality

A

Variola major

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23
Q

What strains are used to make smallpox vaccines?

A
  • Cowpox (originally used)
  • Vaccinia (currently used)
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24
Q

What pox viruses are related to smallpox?

A
  • Monkeypox
  • Molluscum contagiosum (MCV)
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25
Poxviruses are the _____ of dsDNA viruses. They have _____ replication
Largest; atypical
26
Do poxviruses need host DNA-dependent RNA polymerase?
No - they encode their own viral DNA dependent RNA polymerase in the host cell cytoplasm (don't need to get into the nucleus)
27
Poxviruses transcribe viral DNA in the:
Cytoplasm (not in the nucleus)
28
Poxviruses can be ID'd in the lab via:
Guarnieri bodies
29
Guarnieri bodies are found in _____
All poxvirus infections
30
Guarnieri bodies are known as _____
B-type inclusions (cytoplasmic inclusions in epithelial cells)
31
Smallpox transmission
Inhalation of airborne variola virus
32
Smallpox clinical course
1. Incubation 10-12 days; infection of mouth and nose mucosa; spread by coughing and sneezing 2. Migration to lymph nodes, access to bloodstream and organs 3. Symptoms appear (fever, rash)
33
Smallpox: fever appears ____ after inoculation
2-4 days
34
Describe smallpox rash development (timeline)
- Rash appears day 10-12 (mouth) - Skin rash appears 2-4 days later (forehead, face, then limbs - macules)
35
The prodrome of smallpox occurs between __-__ days. Why is this important?
0-12 days; already infectious but don't have the pox yet
36
Smallpox lesions (pocks) are all in the:
Same stage of development
37
Smallpox lesions most dense on:
Face, arms and palms, legs and soles
38
Smallpox was ____ in 1980
Eradicated
39
How was smallpox eradicated?
- Vaccine (half life 92 years) - No animal vectors
40
True or false: population is now susceptible to smallpox
True
41
Smallpox is a potential ______
Bioterrorism agent (most infectious before pox appear)
42
How was the cowpox vaccine initially developed?
- Edward Jenner infected a boy with cowpox - Later inoculated the same boy with smallpox - Immunized boy was not infected with smallpox
43
Vaccinia makes a highly effective:
Smallpox vaccine
44
____ is not the same as cowpox
Vaccinia
45
True or false: it is of unknown origin how Vaccinia became the smallpox vaccine
True
46
____ is directly responsible for smallpox eradication
Vaccinia (smallpox vaccine)
47
Smallpox vaccine (Vaccinia) is a ____
Live vaccine
48
Vaccinia may cause adverse events after vaccination. The smallpox vaccine is not recommended for:
- AIDS patients (Vaccinia necrosum) - Eczema, atopic dermatitis (Eczema vaccinatum) - Chemotherapy cancer patients - Organ transplant patients - Pregnant women (Congenital vaccinia)
49
Monkeypox had a ____ outbreak in 2022-2023
Worldwide
50
Monkeypox transmission
Viral zoonotic disease (infects people, small animals, rodents)
51
Monkeypox resembles ____ clinically
Smallpox
52
You can use ____ to vaccinate against Monkeypox
Smallpox vaccine (provides protection)
53
_____ causes epidermal tumors
Molluscum contagiosum (MCV)
54
MCV causes what kind of lesions?
Doughnut shaped; Umbilication
55
MCV causes disfiguring disease in ____ patients
HIV/AIDS
56
Parvovirus ____ infects humans
B19
57
Parvovirus contains what genetic material?
ssDNA
58
Parvovirus is associated with ____ disease
"Fifth"
59
Parvovirus B19 targets:
Precursors of red blood cells in bone marrow
60
Parvovirus B19 causes what symptoms?
- Erythema infectiosum (infectious rash) - "Fifth" disease (exanthematous rashes) - "Slapped cheek syndrome"
61
Slapped cheek syndrome rash looks like:
Lace-like, follows face rash on trunk and/or extremities
62
Parvovirus B19 complications most severe in:
- Pregnant women (if it crosses placenta) - Other blood disease patients (chronic anemia, sickle cell)
63
What can happen if Parvovirus B19 crosses the placenta?
- fetus can develop severe anemia - lyse RBC and affect RBC precursors in fetus - Hydrops fetalis (fetus can die in utero)
64
Parvovirus B19 infection in sickle cell patients can cause:
- Aplastic crisis (stops blood cell production) - Reticulocytopenia (decreases RBC production)

DEN 7108 Micro and Immuno Concepts Part II (27 decks)

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