[2] Chemotherapy and Complications of Treatment Flashcards Preview

[OS 217] Oncology > [2] Chemotherapy and Complications of Treatment > Flashcards

Flashcards in [2] Chemotherapy and Complications of Treatment Deck (19)
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1

How do you improve phase specific agents for chemotherapy?

Increase the exposure time

2

Magic number of chemotherapy cycles

6

3

Fractional cell killing doesn't completely work because of what reason?

It assumes that all cells are continuously in dividing stages but some can reach a plateau stage and it won't be effective here

4

Alternating chemotherapy is only effective against this sarcoma

Ewing's Sarcoma

5

Define: Measurable Lesion

Lesions that can be accurately measured in at least one dimension with longest diameter

6

Define: Complete Response

Disappearance of all target lesions

7

Define: Partial Response

>= 30% decrease in Sum of Longest Diameter when compared to Baseline

8

Define: Progressive Disease

>= 20% increase in Sum of Longest Diameter since initiation of treatment or appearance of new lesions

9

Chemotherapy is a mixed contraindication to chemotherapy, which trimester is it most dangerous to give?

1st Trimester

10

If you had previous cytotoxic chemotherapy how much time must pass before you can have another round of chemotherapy?

No less than 2 weeks time (Bone marrow has to recover from the 12 day danger period)

11

Deadliest side effect of chemotherapy

Bone marrow failure

12

Monitoring for leukopenia and neutropenia should be done after at least how many days post-chemotherapy? Why is this so?

At least 7-10 days post-chemotherapy

Circulatory lymphocytes have a lifespan of 7-10 days

13

An effective treatment drug for Estrogen Receptor + BRCA

Tamoxifen

14

Function: Aromatase Inhibitors

Inhibits aromatase to block peripheral conversion of Androstenedione -> Estrone (No Estrone -> Estradiol)

15

Aromatase Inhibitors should only be given to these patients

Post-menopausal women

16

If you want to give aromatase inhibitors to a pre-menopausal woman you must do this as well

Block LHRH
Ovary removal

17

[Mechanism of Action]

Sorafenib

Inhibiting raf and VEGFR

18

[Mechanism of Action]

Bevacizumab

Inhibition of VEGF

19

Chemotherapeutic drugs ending in '-nib' work via?

Small molecular ihibition