2. Inflammatory Bowel Diseases Flashcards Preview

BDS2 BAMS Gastroenterology > 2. Inflammatory Bowel Diseases > Flashcards

Flashcards in 2. Inflammatory Bowel Diseases Deck (32):
1

Types of inflammatory bowel diseases (2)

Crohn's disease (CD)
Ulcerative colitis (UC)

2

Aetiology of IBDs (4)

Immunological
Psychological
Smoking
Genetics

3

Cause of Crohn's

Granulomatous inflammation/non-caseous granulomas

4

Reasons for granulomatous inflammation/non-caseous granulomas (2)

Food intolerance
Persisting viral infection/immune activation

5

Most commonly affected body parts for Crohn's (2)

Proximal colon
Terminal ileum

6

Feature of Crohn's

Skip lesions may be present (oral/anal symptoms - top and tail)

7

Features of UC (5)

Ulcers just in mucosa
Continuous along colon
More bleeding than Crohn's
Absence of goblet cells, distortion of crypts
Flat and vascular - not much swelling

8

Definition of granuloma

Build-up of immune and epithelioid cells

9

Differences between UC and Crohn's - UC (7)

Disease continuous
Rectum always involved
Anal fissures - 25%
Ileum involved - 10%
Mucosa granulomatous and ulcers present
Vascular
Normal serosa

10

Differences between UC and Crohn's - Crohn's (7)

Disease discontinuous
Rectum involved 50%
Anal fissures - 75%
Ileum involved - 30%
Mucosa cobbled and fissures present
Non-vascular
Inflamed serosa

11

Crohn's vs UC - continuous disease or not

Crohn's - disease discontinuous
UC - disease continuous

12

Crohn's vs UC - rectum involvement

Crohn's - involved 50%
UC - always involved

13

Crohn's vs UC - anal fissures

Crohn's - 75%
UC - 25%

14

Crohn's vs UC - ileum involvement

Crohn's - involved 30%
UC - involved 10%

15

Crohn's vs UC - mucosa presentation

Crohn's - cobbled and fissures present
UC - granulomatous and ulcers present

16

Crohn's vs UC - vascularity

Crohn's - non-vascular
UC - vascular

17

Crohn's vs UC - serosa presentation

Crohn's - serosa inflamed
UC - serosa normal

18

Microscopic features of UC (3)

Mucosal
Vascular
Mucosal abscesses

19

Microscopic features of Crohn's (3)

Transmucosal
Oedematous
Granulomas

20

UC symptoms (7)

Diarrhoea
Abdominal pain
PR bleeding
Bile motions
Mucus
Urgency
Tenesmus

21

Crohn's symptoms (6)

Colonic disease (same as UC)
Small bowel disease (pain, obstruction, malabsorption)
Mouth disease (OFG)

22

Vitamins involved in malabsorption (3)

Iron
Vitamin B12
Folate

23

OFG clinical features (5)

Lip swelling
Angular cheilitis
Cobblestoning
Ulceration
Gingivitis

24

IDB investigations (3)

Blood tests (anaemia, CRP, ESR)
Faecal calprotectin
Endoscopy
(leukocyte scans, barium studies, bullet endoscopy)

25

Complications of UC (4)

Carcinoma
Perforation
Bleeding
Toxic megacolon

26

Complications of Crohn's (2)

Obstruction
Abscess formation

27

Drugs involved in medical treatment of IBDs (5)

Systemic steroids (prednisone)
Local steroids (rectally administered)
Anti-inflammatories (5-ASAs - mesalazine)
Non-steroid immunosuppressants (azathioprine)
Anti-TNFa therapy (infliximab)

28

Surgical treatment of IBDs results in

A stoma/bag

29

Surgical treatment of UC

Colectomy - cures UC

30

Surgical treatment of Crohn's (4)

Palliate symptoms
Remove obstructed bowel symptoms
Drain abscesses
Close fistulae (especially perianal)
Usually only when acute problems manifest

31

Characterisation of OFG

Persistent enlargement of soft tissues of mouth, lips and area around the mouth

32

Oral ulcers are worse when

UC is worse