3. Coeliac Disease Flashcards Preview

BDS2 BAMS Gastroenterology > 3. Coeliac Disease > Flashcards

Flashcards in 3. Coeliac Disease Deck (16):
1

Definition of coeliac disease

Sensitivity to a-gliaden component of gluten

2

Aetiology of coeliac disease (3)

Genetics (DQW2)
T lymphocytes
Villous atrophy

3

What dose gluten sensitive enteropathy involve

Subtotal villous atrophy of the jejunum

4

Effects of jejunal atrophy (2)

Variable
Clinical (30-40%) - growth failure, oral ulceration
Subclinical

5

Classic symptoms of coeliac disease (8)

Weight loss
Lassitude
Weakness
Abdominal pain/swelling
Diarrhoea
Aphthae/glossitis
Steatorrhoea
Dysphagia

6

Coeliac is usually the result from the malabsorption of (4)

Iron
Folat
Vitamin B12
Fat

7

Coeliac disease investigations (4)

Jejunal biopsy (capsule, endoscope)
Faecal fat
Haematinics
Auto-antibodies - serum transglutaminase, anti-gliaden/anti-endomyseal antibodies

8

Management of coeliac disease

Adhering to gluten-free diet

9

Adhering to gluten-free diet can lead to (3)

Reversal of jejunal atrophy
Improved well-being
Reduced risk of lymphoma

10

Coeliac disease is associated with

Dermatitis herpetiformis

11

What is dermatitis herpetiformis (2)

Oral disease
Involves granular IgA deposition in skin and mucosa

12

Colonic carcinoma symptoms (3)

Relatively symptomless
Anaemia
Rectal blood loss

13

Colonic carcinoma screening involves (5)

FOB
Barium enema
Endoscopy
CT/MRI scan
Carcinoembryonic antigen (CEA)

14

Aetiology of colonic carcinoma (7)

Intestinal polyps
Diet
Smoking
Alcohol consumption
Reduced exercise
Genetics (p53 in 75%)
UC

15

Polyps may (2)

Be pedunculate or flat
Bleed due to irritation and trauma

16

Treatment for colonic carcinoma (4)

Surgery
Hepatic metastases
Radiotherapy
Chemotherapy