2 Year 2 CHD Flashcards
(16 cards)
It is
Most common cause of death in Uk
More many deaths are premature
30%
Effects of GTN
throbbing headache and dizziness
BP and GTN?
↓BP which is compensated by ^HR
Where is GTN metabolised?
Rapidly in liver
Process of GTN?
Produces NO -> ^cGMP -> muscle relaxes
Nitrovasodilators dilate
both arteries and veins.
Dilating systemic arteries…
↓resistance& BP ->less work for heart (less demand)
Dilating large veins…
^blood in venous system. less back to
Why throbbing headache?
Cerebral blood flow increased from dilating cerebral arteries.
Sildenafil?
Other drug acting on NO pathway.
Low CHD risk with
high HDL
How do statins work?
HMG-CoA reductase inhibitors. Mostly cholesterol reducing.
Which drug only lowers cholesterol?
Resins
Which drug only lowers triglyceride?
Metformin
Which drug reduces both cholesterol and triglyceride equally?
Nicotonic acid
