2009 lessons mcq Flashcards Preview

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Flashcards in 2009 lessons mcq Deck (19):
1

acute phase response involves

involves the liver, raised CRP and IL-1

2

NK cells

are of the myeloid lineage
have an FcgammaR

3

in granulation tissue

metalloproteinases are required for tissue remodelling
there is increased MHC expression

4

the Fc portion can

- is required for IgA mucosal trasfer
- imp in triggering IgE mediated hypersensitivity
- of IgG can activate C1q

5

lymphocyte activation

CD28 is present on T cells
cross linking CD40 on B cells promotes their proliferation

6

cytokines

IL-12 is proinflammatory
IL4 drives Th2 responses
IL8 is chemotactic for neutrophils
IFNgamma is proinflammatory

7

Th1 is -
Th2 is -

Th1 is cell mediated
Th2 is humoural mediated

8

Th1 responses are

important in controlling mycobacterial infections
and are promoted by high TCR affinity

9

CD4 and CD25+ cells?

supressor cells that may control autoreactive T cells

10

autoimmunity

immune complex deposition my cause vasculitis
most autoimmune disease show a genetic ASSOCIATION with MHC

11

transplantation, indirect recognition?

is due to uptake of allogenic proteins by the recipient's own antigen presenting cells

12

HSV encodes

a ribonucleotide reductase
is dsDNA
replicates in the nucleus

13

HIV can be acquired congenitally

-

14

poliovirus is

a picornavirus
ssRNA
posseses an IRES
has an icoahedral capsid
transmitted faeco-orally

15

acyclovir (zovirax)

inhibits HSV DNA replication and is an analogue of thymidine

16

influenza HA permits

infection of erythrocytes

17

transmissible spongifor encephalopathies are

caused by abnormally folded PrP molecules
can be transmitted orally
can be inherited
degenerate the CNS
cannot be vaccinated against

18

plasmodium falciparum

glycosyl phosphatidyl inositol (GPI) is proinflammatory
sporozoites invade liver cells
sequestration of infected RBCs is via var gene products
thalassaemias can confer protection

19

parasites

onchocerca volvulus is the black fly bite transmited parasite causing river blindness
in humans, helminths generally elicit a Th2 response
wucheria bancrofti produces microfilaria and is one of three parasites that can cause filariasis and is transmitted by mosquitos