immunity and inflammation Flashcards
what are the four classifications of hypersensitivity?
Types 1-4
type 1
IgE mediated
Type 2
tissue specific specific to cell or tissue and no other sign of cell mediated IgG and IgM mediated grave's disease blood agglutination
type 3
immune complex mediated
type 4
cell mediated
which types is a response to an allergen?
type 1
allergen
an antigen that causes an allergic reaction; typically foreign proteins from the environment
what are some common allergens
gluten animal dander pollen rag weed dust mites milk protein
what are characteristics of a type 1 allergic hypersensitivity?
hives
bronchiole constriction
diarrhea
skin irritation
which type of allergic reaction leads to anaphylactic shock?
type 1
what are the characteristics of anaphylactic shock?
vasodilation peripheral pooling relative hypovolemia decreases tissue perfusion impaired cellular metabolism
what would you give someone to reverse the effects of anaphylactic shock?
epinephrine
tissue specificity
all tissue have specific markers or receptors
what are the five steps of type 2 hypersensitivity?
before the five steps there is antibody binding
1-complement mediated lysis
2.phagocytosis by macrophage
3-neutrophil-mediated damage
4-antibody-dependent cell-mediated cytotoxicity (NK cells)
5-cellular malfunction
in type 3, rather than binding to specific antigen (as in type2), on tissues…
effects are mediated by large complexes of antibodies
