Renal 1

Question 1

Glomerulopathie involving epithelial cells only (1)

Answer 1

Minimal change

Question 2

Glomerulopathies involving epithelial cells and basement membrane (2)

Answer 2

FSGS,

Membranous

Question 3

Gomerulopathies involving basement membrane only (5)

Answer 3

Diabetes,
Amyloid,
Light chain deposition dz,
Alports,
Thin basement membrane dz

Question 4

most common cause of nephrotic syndrome in children

Answer 4

minimal change

Question 5

EM findings n minimal change

Answer 5

effacement of epithelial foot processes

Question 6

Most common cause of idiopathic neprhotic syndrome in AA adults

Answer 6

FSGS

Question 7

secondary causes of FSGS (5)

Answer 7

Obesity,
sickle cell,
pre-eclampsia, 
reflux nephropathy,
unilateral kidney

Question 8

Nephropathy that may have intracapillary foam cells

Answer 8

FSGS

Question 9

Aggressive variant of FSGS

Answer 9

collapsing

Question 10

IF in FSGS

Answer 10

negative or non-specific

Question 11

EM of FSGS

Answer 11

foot process effacement, epithelial cell vacuolization

Question 12

HIV nephropathy on LM

Answer 12

collapsing FSGS

Question 13

HIV nephropathy on EM

Answer 13

tubulo-reticular inclusions in epithelial cells (also seen in lupus)

Question 14

Diseases with tubulo-reticular inclusions on EM

Answer 14

HIV and Lupus

Question 15

Most common cuase of idiopathic nephrotic syndrome in white adults

Answer 15

membranous nephropathy

Question 16

LM of membranous nephropathy

Answer 16

capillary loops thickened

Question 17

Silver stain in membranous

Answer 17

“spikes”

Question 18

IF in membranous

Answer 18

granular IgG adn C3 on capillary loops

Question 19

Granular IgG and C3 on capillary loops

Answer 19

Membranous

Question 20

“spikes”

Answer 20

membranous

Question 21

Location of deposits in membranous

Answer 21

subepithelial

Question 22

Stage 1 membranous

Answer 22

subepithelial deposits without GBM thickening

Question 23

Stage 2 membranous

Answer 23

“spike and dome”

Question 24

Stage 3 membranous

Answer 24

deposits completely surrounded by GBM

Question 25

Stage 4 membranous

Answer 25

“moth-eaten” GBM, deposits resorbed

Question 26

Secondary causes of membranous (5)

Answer 26

RA,
Drugs (gold, penicillamine),
paraneoplastic,
Hep B and C,
lupus

Question 27

IF of lupus nephritis

Answer 27

C1q deposits

Question 28

Classic lesion of diabetic nephropathy

Answer 28

Kimmelstiel-Wilson nodules

Question 29

IF of diabetic nephropathy

Answer 29

nonspecific linear IgG and albumin on BM

Question 30

Em of diabetic

Answer 30

diffuse thickening of GBM