Renal 2 Flashcards
Clinical scenarios of AA amyloid
chronic inflammation
RA
“skin-poppers”
Most common light chain related renal dz
light chain cast nephropathy
2nd most common light chain related renal dz
AL amyloid nephropathy
Most patients with AL amyloid do/do not have myeloma
do not
most patiets with light chain cast nephropathy do/do not have myeloma
do
fracutred eosinophilic casts surrounded by multinucleated cells
light chain cast nephropathy
Amyloid is more often kappa or lambda?
lambda
Light chain deposition dz is more often kappa or lambda?
kappa
LM in light chain deposition dz
nodular mesangial (like K-W nodules)
IF in light chain deposition dz
linear kappa or lambda tubular nad GBM staining
Linear kappa or lambda tubular and GBM staining
light chain deposition disease
EM: Granular deposits on tubular and glomerular BM
light chain depostion dz
Vessels with “onion-skinning” and mucoid intimal hyperplasia
scleroderma and malignant HTN
arteral lumen occluded by plaque with cholesterol clefts
atheroembolic dz
diffuse glomerulonephritis (4)
Post-infectious,
Membranoproliferative,
Lupus,
bacterial endocarditis
