Pediatric pharm Flashcards
Medications that have increased absorption in neonates
penicillins, erythromycin
Medication with decreased absorption in neonates
acetaminophen
Due to the increased permeability of infant’s skin, what should be used with caution?
steroid containing preparation, iodine absorbed from Betadine
Percent of body weight in neonates that is ECF
40%
Describe the difference of plasma protein binding in neonates
decreased concentration of total protein, decreased binding affinity, presence of bilirubin
For children aged 6 months -2yrs, what amount needs to be given for anticonvulsants
2-5x the adult does
Describe GFR in infants and children and it’s effect on drug administration
GFR very rapid, drugs eliminated by GFR administered at shorter intervals
Common overdoses in pediatrics
iron supplements and acetaminophen
How do GI and IM absorption differ in infants/children compared to adults?
Infants and children generally absorb medications more rapidly and completely than adults
Two drugs to avoid in pediatrics
propylene glycol and benzyl alcohol
How many cc or ml equals one teaspons
5cc or 5 ml
Route of acetaminophen administration that is discourage due to wide variation of effects
rectal
Percent of caregivers unable to dose Tyelonol and Motrin properly
50%, most commonly underdosing
Fever reducer not labeled for infants < 6 months
Motrin
Dose of ibuprofen
5-10mg/kg per dose, every 6 hours. Reserve the 10mg/kg for high fevers
