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[Immunohematology] Lec > [24] CHAPTER X LESSON 2 > Flashcards

[24] CHAPTER X LESSON 2 Flashcards

1
Q

Symptomatic anemia with large-volume deficit

A

Whole blood

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2
Q

Increases oxygen-carrying capacity

A

Whole blood

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3
Q

Increases blood volume

A

Whole blood

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4
Q

Infectious diseases

A

Whole blood

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5
Q

Hemolytic, septic/ toxic, allergic, febrile reactions

A

Whole blood

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6
Q

Iron overload, TACO, TRALI, TA-GVHD

A

Whole blood

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7
Q

Must be ABO identical

A

Whole blood

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8
Q

Symptomatic anemia; red blood cell exchange transfusion

A

Red blood cells: RBCs (adenine-saline added), RBC pheresis

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9
Q

Increases oxygen- carrying capacity

A

Red blood cells: RBCs (adenine-saline added), RBC pheresis

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10
Q

Same as whole blood category, above

A

Red blood cells: RBCs (adenine-saline added), RBC pheresis

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11
Q

IgA deficiency with anaphylactoid/ anaphylactic reaction

A

Red blood cells: RBCs (adenine-saline added), RBC pheresis

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12
Q

Severe allergic reactions, rare donors, symptomatic anemia; red blood cell exchange transfusion

A

Red blood cells: deglycerolized, washed

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13
Q

Deglycerolization removes plasma proteins.

A

Red blood cells: deglycerolized, washed

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14
Q

Risk of allergic and febrile reactions reduced; increases oxygen-carrying capacity

A

Red blood cells: deglycerolized, washed

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15
Q

Same as RBCs above

A

Red blood cells: deglycerolized, washed

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16
Q

Hemolysis due to incomplete deglycerolization can occur.

A

Red blood cells: deglycerolized, washed

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17
Q

Symptomatic anemia

A

Red blood cells: leukocyte-reduced

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18
Q

Febrile reactions due to leukocyte antibodies

A

Red blood cells: leukocyte-reduced

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19
Q

Reduction of CMV

A

Red blood cells: leukocyte-reduced

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20
Q

Leukocyte reduction is achieved by filtration:
(1) soon after collection (pre-storage) or
(2) after varying periods of storage in the laboratory

A

Red blood cells: leukocyte-reduced

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21
Q

Same as RBCs transmission and HLA alloimmunization

A

Red blood cells: leukocyte-reduced

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22
Q

Hypotensive reaction may occur if bedside leukocyte- reduction filter is used.

A

Red blood cells: leukocyte-reduced

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23
Q

RBCs leukocyte-reduced must have a residual content of leukocytes <5 × 106 WBC and ≥85% of the original red blood cell content.

A

Red blood cells: leukocyte-reduced

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24
Q

Bleeding due to thrombocytopenia or platelet function abnormality including antiplatelet drugs

A

Platelets/apheresis platelets

Platelets leukocytes reduced/apheresis platelets leukocytes reduced

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25
Q

Prevention of bleeding from marrow hypoplasia

A

Platelets/apheresis platelets

Platelets leukocytes reduced/apheresis platelets leukocytes reduced

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26
Q

Improves hemostasis

A

Platelets/apheresis platelets

Platelets leukocytes reduced/apheresis platelets leukocytes reduced

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27
Q

Apheresis platelets may be HLA (or other antigen) selected.

A

Platelets/apheresis platelets

Platelets leukocytes reduced/apheresis platelets leukocytes reduced

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28
Q

Septic/toxic, allergic, febrile reactions

A

Platelets/apheresis platelets

Platelets leukocytes reduced/apheresis platelets leukocytes reduced

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29
Q

Infectious diseases

A

Platelets/apheresis platelets

Platelets leukocytes reduced/apheresis platelets leukocytes reduced

Apheresis granulocytes

Plasma (liquid)

Cryoprecipitate pooled/ cryoprecipitated AHF

Fresh-frozen plasma (FFP)

30
Q

TACO, TRALI, TA-GVHD

A

Platelets/apheresis platelets

Platelets leukocytes reduced/apheresis platelets leukocytes reduced

31
Q

One unit of platelets derived from a whole blood collection usually contains ≥5.5 × 1010 platelets suspended in 40 to 70 mL of plasma.

A

Platelets/apheresis platelets

32
Q

One unit of apheresis platelets usually contains ≥ 3 × 1011 platelets/ unit and is the therapeutic equivalent of 4 to 6 units of platelets.

A

Platelets/apheresis platelets

33
Q

Prevention of febrile reactions, HLA alloimmunization and CMV infection

A

Platelets leukocytes reduced/apheresis platelets leukocytes reduced

34
Q

May be prepared using an open or closed system.

A

Platelets leukocytes reduced/apheresis platelets leukocytes reduced

35
Q

One unit of platelets leukocyte-reduced should contain >5.5 × 1010 platelets and <8.3 × 105 leukocytes.

A

Platelets leukocytes reduced/apheresis platelets leukocytes reduced

36
Q

Components prepared using an open system will expire 4 hours after preparation.

A

Platelets leukocytes reduced/apheresis platelets leukocytes reduced

37
Q

Neutropenia with infection unresponsive to appropriate antibiotics

A

Apheresis granulocytes

38
Q

Increases the level of granulocytes to phagocytize and kill bacterial and fungal infections

A

Apheresis granulocytes

39
Q

Hemolytic, allergic, febrile reactions

A

Apheresis granulocytes

40
Q

Must be ABO compatible

A

Red blood cells: RBCs (adenine-saline added), RBC pheresis

Red blood cells: deglycerolized, washed

Apheresis granulocytes

Plasma (liquid)

Fresh-frozen plasma (FFP)

PF24 (Plasma frozen within 24 hours after phlebotomy)

PF24RT24 (Plasma frozen within 24 hours after phlebotomy held at room temperature

Thawed plasma

Thawed plasma, cryoprecipitate reduced

41
Q

Contain numerous leukocytes and platelets as well as 20 to 50 mL of RBCs; the number of granulocytes in each concentrate is usually >1 × 1010 granulocytes/unit.

A

Apheresis granulocytes

42
Q

Initial treatment of patients

A

Plasma (liquid)

43
Q

Coagulation support for lifethreatening trauma, hemorrhages

A

Plasma (liquid)

44
Q

Undergoing massive transfusion

A

Plasma (liquid)

45
Q

Allergic and febrile reactions, TACO, TRALI

A

Plasma (liquid)

Fresh-frozen plasma (FFP)

PF24 (Plasma frozen within 24 hours after phlebotomy)

PF24RT24 (Plasma frozen within 24 hours after phlebotomy held at room temperature up to 24 hours after phlebotomy)

Thawed plasma

Thawed plasma, cryoprecipitate reduced

46
Q

Hypofibrinogenemia

A

Cryoprecipitate pooled/ cryoprecipitated AHF

47
Q

Factor XIII deficiency (Second line therapy for von Willebrand’s disease, hemophilia A, and uremic bleeding)

A

Cryoprecipitate pooled/ cryoprecipitated AHF

48
Q

Provides fibrinogen (factor I), factors VIII, XIII, and vWF

A

Cryoprecipitate pooled/ cryoprecipitated AHF

49
Q

Allergic and febrile reactions

A

Cryoprecipitate pooled/ cryoprecipitated AHF

50
Q

Must contain >150 mg of fibrinogen in each unit of cryoprecipitate

A

Cryoprecipitate pooled/ cryoprecipitated AHF

51
Q

Cryoprecipitated AHF should contain >80 IU of factor VIII in each unit.

A

Cryoprecipitate pooled/ cryoprecipitated AHF

52
Q

Clinically significant plasma protein deficiencies when no specific coagulation factor concentrates are available

A

Fresh-frozen plasma (FFP)

PF24 (Plasma frozen within 24 hours after phlebotomy)

53
Q

TTP

A

Fresh-frozen plasma (FFP)

PF24RT24 (Plasma frozen within 24 hours after phlebotomy held at room temperature up to 24 hours after phlebotomy)

Thawed plasma

Thawed plasma, cryoprecipitate reduced

54
Q

Source of all coagulation proteins and plasma proteins

A

Fresh-frozen plasma (FFP)

55
Q

Source of nonlabile plasma proteins

A

PF24 (Plasma frozen within 24 hours after phlebotomy)

56
Q

Levels of factor VIII are significantly reduced and levels of factor V and other labile plasma proteins are variable compared with FFP.

A

PF24 (Plasma frozen within 24 hours after phlebotomy)

57
Q

Clinically significant deficiency of stable coagulation factors when no specific coagulation factor concentrates are available

A

PF24RT24 (Plasma frozen within 24 hours after phlebotomy held at room temperature up to 24 hours after phlebotomy)

Thawed plasma

58
Q

Source of nonlabile plasma proteins

A

PF24RT24 (Plasma frozen within 24 hours after phlebotomy held at room temperature up to 24 hours after phlebotomy)

59
Q

Levels of factor V, factor VIII, and protein S are significantly reduced, and levels of other labile plasma proteins are variable compared with FFP

A

PF24RT24 (Plasma frozen within 24 hours after phlebotomy held at room temperature up to 24 hours after phlebotomy)

60
Q

Source of plasma proteins and contains stable coagulation factors (factor II, fibrinogen), similar clinically to the levels found in FFP; other factors are variable, being reduced in levels that change over time.

A

Thawed plasma

61
Q

Plasma protein replacement for plasma exchange in TTP; this product contains variable levels of albumin, ADAMTS13, and factors II, V, VII, IX, X, and XI.

A

Thawed plasma, cryoprecipitate reduced

62
Q

TACO =

A

transfusion-associated circulatory overload

63
Q

TRALI =

A

transfusion-related acute lung injury

64
Q

TA-GVHD =

A

transfusion-associated graft-vs-host disease

65
Q

CMV =

A

cytomegalovirus

66
Q

TTP =

A

thrombotic thrombocytopenic purpura

67
Q

AHF = antihemophilic factor

A
68
Q

ITP =

A

immune thrombocytopenic purpura

69
Q

vWF =

A

von Willebrand factor

70
Q

HLA =

A

Human Leukocyte Antigen

71
Q

IUT =

A

intrauterine transfusion

[Immunohematology] Lec (35 decks)

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