immune reactions to drugs

Question 1

Which antibody is most associated with Type I hypersensitivty

Answer 1

IgE

Question 2

which antibody is associated with type 2 and 3

Answer 2

IgG

Question 3

what two reactions are common with type 3 hypers.

Answer 3

Arthus reaction and serum sickness

Question 4

how can an Arthus reaction occur?

Answer 4

at the site of tetanus immunizations when given in too short of an interval (can sometimes look like cellulitis)

Question 5

Describe atopy

Answer 5

a hereditary predisposition to being hypersensitive to allergens, often present with classic triad (eczema, astha, and hay fever)

Question 6

how can angioedema be caused by two different pathways?

Answer 6

It can be IgE mediated through release of histamine from mast cells…. or nonIgE through autoimmune disease or ACE inhibitors causing mast cells to release bradykinin

Question 7

describe anaphylactoid reactions

Answer 7

similar to anaphylaxis but non IgE mediated…

Question 8

describe type ii hypersensitivity

Answer 8

IgG binds to antigens activates complement. a MAC forms and lyses cells…

Question 9

what are hallmark problems from type 2

Answer 9

anemia, transfusion rxns, or Rh rxns

Question 10

in type 3 describe

Answer 10

antibody-antigen complex overwhelms body