Endocrine Flashcards
What is the mechanism of action of Propylthiouracil? What is this for?
What is the Mechanism of action of Methimazole? What is its main side effect?
What is Leveothyroxine and Triiodothyronine?
How do I remember this shit?
Inhibits peroxidase (source of organic Iodine) and 5’-deiodinase (Conversion of T4 => T3). Hyperthyroidism.
Inhibits peroxidase. Possibly Teratogenic.
Thyroid replacement
Propylthiouracil Prohibits Thyroid in all forms. Meth is Amazing at keeping from eating like Methimazole, but Methimazole leads to lack of energy/not increased. Leveothyroxine is easy and Triiodothyronine think T3.
What is Octreotide? Which causes?
What is Desmopressin? Which causes?
What is Glucocorticoids? Which inhibits what?
Synthetic Somatostatin. Inhibits many other hormones (Like an Octopus grabbing eight things and holding on to them)
Synthetic ADH (Vasopressin). Increase collecting ducts/reabsorb urea(V2) and Vasoconstriction(V1).
Synthetic Cortisol. Phospholipase A2** and **COX-2** (Are you **2** scared and have a **limp COX)
What are the classic short acting insulins?
Intermediate acting?
Long acting?
Lispro and Aspart
NPH
Glargine and Detemir
What is the mechanism of action of Sulfonylureas?
What are the 1st generation Sulfonylureas? What is their unique side-effect?
What are the 2nd generation Sulfonylureas? What is their (dis)advantage?
How do I remember this shit?
Closes K channel in β cells => insulin release (so only DM 2)
Tolbutamide** and Chlorprop_amide_** (Disulfiram-like)
Gly**bur**ide**, **Gli**mepir**ide**, and **Gli**piz**ide (More effective)
If you can Su**r**f on your ureas, you needam**y t**ide**protection 1st but you can’t drink with it and we be**closing**those gates**K**. If you want sometin more powerful,**Gl**ad B**Ide and I to help ya.
What is the Biguanide?
What is its mechanism of action?
What is the Major side effect of it?
How do I remember this shit?
Metformin.
Unkown, Decreases gluconeogenesis (Increase glycolysis/glucose uptake).
Lactic acidosis
Have you Met** the **formin** that is cleaning up this **Big** _Guan_o mess? He has stopped making lunches and I’m worried he is on **Acid?
What are the glitazones?
What is their mechanism of action?
What are the side effects?
How do I remember?
Pioglitazone**/Rosi_glitazone_**.
PPAR-γ nuclear transcription regulator => Insulin sensitivity.
Weight gain, edema, hepatotoxicity, heart failure.
Glitter PPAR** **zone is to make you more sensitive to homosexuality, but careful you don’t reject it and be a fat drunk
What are the α-glucosidase inhibitors?
What is α-glucosidase?
Acarbose(No Carb dose) and Miglitol(just a Mig** **little more than just artificial sugar)
intestinal brush border enzyme for glucose absorption => GI distress
What is Pramlintide?
A Glucagon antimimetic (Pram** **lint** in **Ide belly button to trick the body it is full)
What is Exenatide?
What does it do?
What are its side effects?
GLP-1(Glucagon-like Protein) analog.
Decreases glucagon and Increases insulin.
GI distress/Pancreatitis.
Exen out the idea of Pramlintide and adding a tide of hormones into the pancreas.
