Cell Bio Lecture 7 - Cell Birth and Death Pt. 1 Flashcards
Define regeneration (the altered proliferative state). Can it be pathological?
One for one replacement of cells. Always physiologic.
Define hyperplasia (the altered proliferative state). Can it be pathological?
An increase in the usual number of normal cells. Can be either physiologic or pathological.
Define metaplasia (the altered proliferative state). Can it be pathological?
Replacement of one cell type with another. It is pathological - often a response to injury.
Define dysplasia (the altered proliferative state). Can it be pathological?
Often a precursor to cancer. Cells change mitotic rates, lose positional control, cell shape and size uniformity.
What are the two forms of neoplasia?
Benign and malignant
What are the hallmarks of a malignant neoplasia?
Loss of proliferative AND positional control.
What is liver regeneration an example of?
Regeneration
Name two examples of cell regeneration.
Liver regeneration and endothelial cell regeneration after vascular surgery.
What is restenosis after balloon angioplasty an example of?
Hyperplasia
Name two examples of pathological hyperplasia and one example of physiological hyperplasia.
Pathological: hyperthyroidism and restenosis after vascular surgery.
Physiological: Erythrocyte hyperplasia in bone marrow following blood loss.
Name two examples of metaplasia.
Pelvic inflammatory disease and lung metaplasia in smokers.
In pap smear tests, what cells are tested and what are they examined for?
Exocervical cells are tested for dysplasia.
What are uterine fibroids an example of?
Benign neoplasia.
Is cancer a form of malignant neoplasia?
Yes!
What example of positional control did Dr. Castellot use? What was the jist of that shit?
The villi in the gut. The stem cells are slowly dividing at the base of the villus, as they move up they enter a rapidly dividing state, then at the top they stop dividing and just absorb nutrients.
