Exam 2 Diseases - All of them Flashcards
1
Q
Blistering diseases
A
cadherin, keratin defects
2
Q
Glanzmann’s thrombasthenia
A
Integrin defect (integrins bind to fibrinogen for clotting)
3
Q
Menke’s Disease
A
Defective collagen cross-linking
4
Q
Chondrodysplasias
A
Defective collagen II or chondroitin PGs
5
Q
Goodpasture Syndrome
A
autoimmune-collagen IV affects lung and kidneys
6
Q
Alport Syndrome
A
collagen IV mutation affects lung and kidneys
7
Q
Ehler-Danlos syndrome
A
collagen mutation
8
Q
Osteogenesis imperfecta
A
Type I collagen defect
9
Q
Scurvy
A
No collagen hydroxylation
10
Q
Marfan’s syndrome
A
Defective fibrillin (it links elastin together)
11
Q
Angiogenesis
A
matrix metalloproteases degrade ECM proteins for cancer
