Cell Bio Lecture 10 - Cell-cell, cell-matrix interactions Flashcards
How is collagen type I and II arranged to make it so strong?
Orthogonal arrays (like plywood)
Name two organs where the basal lamina function as a filter.
Glomerular filtration in the kidney, and lung alveolus for gas exchange.
What is the most abundant protein in the body? Specifically what organs is this protein found in?
Type I collagen. Found in bone, skin, tendons, ligaments, cornea, internal organs.
How does Type I collagen polymerize?
Into fibrils
How does Type II collagen polymerize?
Into fibrils
How does Type IV collagen polymerize?
Into sheets
Where is Type II collagen found?
Cartilage!, invertebral disc, notochord, vitreous humor.
Where is Type IV collagen found?
Connects Basal lamina to reticular lamina
Where is Type XVIII collagen found?
Basal lamina around blood vessels
What is going on with Menkes Disease?
No collagen cross-linking due to defective copper ATP transporter.
Whats going on with Alport Disease?
Type IV collagen defect - it is absent or nonfunctional leading to kidney failure
What is the defect with Goodpasture Syndrome?
Autoimmune disease that destroys Type IV collagen in the basement membranes of lungs and kidneys.
What discovery regarding Type XVIII collagen is relevant to cancer treatment?
A 20-kD protein was isolated from Type XVIII collagen that has anti-angiogenic effects and is now used for treatment of cancer. It is also called endostatin. It causes apoptosis in newly forming blood vessels.
