leukemias/lymphomas 1

Question 0

Most adult leukemia are

Most childhood leukemia are

Answer 0

Adult: acute myeloid
Child: acute lymphoid

Question 1

Difference between leukemia and lymphoma

Answer 1

Leukemia is In the blood and lymphoma in the lymph nodes

Leukemia replaces hematopoietic population resulting in pancytopenia

Question 2

Most leukemias and lymphomas originate from what cell line?

Answer 2

B cells

Question 3

MDS: myelodysplatic syndrome
What is it?
Microscopic morphology

Answer 3

Ineffective hematopoiesis

Macrocytic Erythroid cells
Hypo granular bilobed nuclear neutrophils (known as pseudo Pelger-Huët anomaly)

Question 4

Four types of leukemias

Answer 4

Acute lymphoid
Chronic lymphoid
Acute myeloid
Chronic myeloid

Question 5

Young child between two and ten with CD10 surface marker with low WBC count

Prognosis?

Answer 5

ALL acute lymphoid leukemia

Good prognosis

Most ALL are precursor BCell type and have surface markers CD10, 19,20

Question 6

CD markers for CLL (chronic lymphoid leukemia)

Answer 6

19,20,23,5

Question 7

Epidemiology of CLL

Answer 7

Age greater than 50
Male to female ratio 2:1
Most common form of leukemia in the US

Question 8

What is Richter transformation

Answer 8

CLL turning into diffuse large B cell lymphoma

5% of cases

Question 9

Microscopic morphology of CLL

Answer 9

Cracked earth appearance
SMUDGE CELLS are cells that broke during prep of slide
High nucleoid to cytoplasm ratio
Large number of white cells

Question 10

Cells that are myeloid in origin?

Answer 10

Red blood cells, megakaryocytes, neutrophils, monocytes

Question 11

Markers for AML (acute myeloid leukemia)

Answer 11

CD13,15,64

Question 12

Auer rods seen in

Answer 12

AML
Type M3 (acute promyelocyte leukemia)
Type M2

Many rods per cell in M3

Question 13

AML can cause what medical emergency?

Answer 13

DIC

Question 14

What kind of leukemia is associated with swollen gums?

Answer 14

Monocytic leukemia (AML M4 M5)

Question 15

Which leukemia is associated with Down syndrome

Presents with pancytopenia, organomegaly, and marrow fibrosis

Answer 15

AML-M7 aka acute megakaryocytic leukemia

Question 16

CML associated with monoclonal proliferation of _____ which is the precursor cell for______

Answer 16

Granulocytes

Neutrophils

Question 17

Philadelphia chromosome associated with what disease?

Answer 17

CML

Question 18

What is Blast Chrisis?

Answer 18

CML progressing to AML or ALL

Poor prognosis

Question 19

Four types of Chronic Myeloproliferative diseases?

Answer 19

CML
Essential thrombocytosis
Polycythemia rubra Vera
Myelofribosis

Question 20

Budd Chiari syndrome
What is it?
Cause?

Answer 20

Retinal vein occlusion due to sludging from high RBC count of polycythemia rubra Vera

Question 21

Bone marrow cells outside of bone, such as in spleen or liver is indicative of…

Answer 21

Myelofibrosis with myeloid metaplasia

Question 22

B symptoms of Hodgkin’s lymphoma

Answer 22

Fever, night sweats, weight loss

Question 23

Most common type of Hodgkin’s lymphoma

Answer 23

Nodular type

Predominant in females

Question 24

Starry sky pattern seen in…

What’s the cellular cause?

Answer 24

Burkitt’s lymphoma

Caused by macrophage engulfing cellular debris

Question 25

B symptoms of Hodgkin’s lymphoma

Answer 25

Fever, night sweats, weight loss

Question 26

Most common type of Hodgkin’s lymphoma

Answer 26

Nodular type

Predominant in females

Question 27

Starry sky pattern seen in

Answer 27

Burkitt’s lymphoma

Caused by macrophage engulfing cellular debris

Question 28

lymphoma arising from MALT

conditions associated with causing this lymphoma

Answer 28

Maltoma
MALT: Mucosa associated lymph tissue

Helicobacter pylori
Hashimoto thyroiditis
Sjogren syndrome