leukemia/lymphoma 4

Question 0

Mutation responsible for Follicular lymphoma

Answer 0

t(14;18)
BCL2 on 18 translocates to Ig heavy chain locus on chromosome 14

BCL2 stabilizes mitochondrial membrane, inhibiting cytochrome C from leaking into cytoplasm, blocking apoptosis. Thus the process of Somatic Hypermutation is broken and cells don’t die in the follicle.

Question 1

Lymph node expansion association
Follicles
Paracortex
Sinus histiocytes (in the medulla)

Answer 1

follicles: rheumatoid arthritis and early HIV
paracortex: viral infection (Epstein Barr, Mononucleosis)
Sinus histiocytes: LN draining tissue with cancer

Question 2

How to tell the difference between follicular lymphoma and hyperplasia

Answer 2

No apoptosis in lymphoma, so there are no macrophages to clear up debris.

Question 3

Mantle Cell lymphoma mutation

Answer 3

t(11;14)
Cyclin D1 on 11 translocates to Ig heavy chain on 14
Promotes G1/S transition in cell cycle

Question 4

When is Marginal Zone lymphoma seen?

Answer 4

Most lymph nodes don’t have a marginal zone, but in chronic inflammation states such as
Hashimoto’s, Sjogren syndrome, H pylori gastritis,
the margin is produced.