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PGI > 28.6.2013(pathology) 51 > Flashcards

28.6.2013(pathology) 51 Flashcards

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0
Q

Endocrine cause of vit B12 deficiency

A

Hyperthyroidism

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1
Q

Starry sky appearance

A

Burkitt lymphoma

PSGN

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2
Q

Megaloblastic Anemia in hemodialysis..cause?

A

Loss of folate

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3
Q

Lymphoma that expresses BCL 1

A

Mantle cell lymphoma

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4
Q

Rx of follicular lymphoma

A

Most responsive to chemotherapy and radiotherapy

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5
Q

Cystic medial necrosis is seen in

A 
Marfan syndrome
Ehlers danlos syndrome IV 
Hypertension
Bicuspid aortic valve
Familial thoracic aortic aneurysm
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6
Q

Dx of lymphoma of stomach

A

Biopsy

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7
Q

Common symptoms of gastric lymphoma

A

Pain
Weight loss
Bleeding

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8
Q

Half life of factor VII

A

4-6hours

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9
Q

Clotting factor with longest half life

A

Factor XIII(11-14 days)

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10
Q

Factor deficiencies that may present without PT or aPTT prolongation

A

V
X
XIII

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11
Q

Lobulated capillary hemangioma

A

Pyogenic granuloma

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12
Q

Risk of bleeding in pyogenic granuloma

A

Bleeds easily

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13
Q

Drugs causing pyogenic granuloma

A

OCP
indinavir
Retinoids

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14
Q

Infectious causes of pyogenic granuloma

A

Bartonella

Staphylococcus

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15
Q

Causes of pyogenic granuloma

A 
Trauma
Pregnancy
AV malformation
Infections
Drugs
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16
Q

Normal platelet count

A

1.5-3 lac/uL

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17
Q

Normal value of RDW

A

11.5-14.5

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18
Q

Hooping pattern is seen in

A

Primary CNS lymphoma

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19
Q

Hooping pattern is demonstrated by

A

Reticulin staining

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20
Q

Most common location of primary CNS lymphoma

A

1.frontal lobe
Deep nuclei
Periventricular zone

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21
Q

Conditions predisposing to primary CNS lymphoma

A 
HIV
EBV
Immunosuppression 
Collagen vascular diseases
  SLE
  RA
  Sjogren
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22
Q

HSP is common in

A

Males in winter

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23
Q

Types of bronchoalveolar carcinoma

A

Mucinous
Nonmucinous
Clara cells
Type 2 pneumocytes

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24
Most common primary in skeletal metastasis
1. breast | 2. prostate
25
Common causes of hereditary spherocytosis
1. ankyrin 2. Band 3 3. spectrin 4. palladin/ band 4.2
26
Splenctomy in hereditary spherocytosis is delayed until atleast
4 yrs of age
27
Screening test for kala azar
Aldehyde test of Napier detects reversed albumin globulin ratio
28
Other name for leishman test
Montenegro test
29
Serological test for kala azar
Direct agglutination test Indirect IF test rk-39 dipstick test ELISA
30
Types of cystic pancreatic neoplasms
Serous cystadenoma(never malignant) Mucinous cystadenoma Intra ductal papillary Mucinous neoplasm Solid pseudo papillary neoplasm
31
Cystic pancreatic neoplasm common in males
IPMN
32
Difference between IPMN and Mucinous cystadenoma
IPMN Common in head Involves larger ducts Lacks thick stroma
33
Most common mutation in pancreatic carcinoma
1. p16/CDKN2A | 2. K RAS
34
Inherited condition with highest risk of pancreatic cancer
Peutz jegher syndrome
35
Tumors showing perineural invasion
Pancreatic carcinoma | Adenoid cystic carcinoma
36
Tumors showing desmoplastic response
IDC of breast Pancreatic Ca Desmoplastic small round cell tumor
37
Pancreatic ca is common in
Head
38
Giant intracranial aneurysm,size
More than 2.5cm
39
Common site of giant intracranial aneurysm
ICA
40
Types of glomus tumor
Solid glomus tumor(most common type) Glomangioma(common in familial type) Glomangiomyoma
41
Chr in glomangioma
Chr 1p | Glomulin gene
42
Common sites of glomangioma
Hand and forearm
43
Least common type of cardiomyopathy
Restrictive
44
Thickening of which valve is seen in hypertrophic cardiomyopathy
Anterior mitral leaflets
45
Drug causing dilated cardiomyopathy
Cocaine
46
Common sites of brain affected by metastasis
Grey white matter junction | MCA,PCA junction
47
Most common Primary that metastasises to brain
Lung ca
48
Breast metastasis to brain commonly affects
Cerebellum and posterior pitutary
49
Least mature erythrocyte precursor
Pronormoblast/ proerythroblast
50
Abundant mitochondria are found in which erythrocyte precursor
Polychromatophilic erythroblast
51
First appearance of Hb in which erythrocyte precursor
Polychromatophilic erythroblast
52
Maximum number of ribosomes are seen in which stage of erythrocyte maturation
Basophilic erythroblast
53
Chromatin condensation begins in which stage of erythropoiesis
Basophilic erythroblast
54
Diff btw Pronormoblast and basophilic erythroblast
Nucleoli is absent in basophilic erythroblast
55
Smallest nucleated erythrocyte precursor
Orthochromatic erythroblast
56
Supravital staining
New methylene blue | Brilliant cresyl blue
57
Diff in metabolism of reticulocytes and RBCs
Intact TCA cycle is present in reticulocytes
58
Drugs causing thrombocytopenia
``` Selective impairment of platelet production Thiazides Alcohol Autoimmune causes Heparin Quinidine Sulfa compounds ```
59
Infections causing thrombocytopenia
HIV measles CMV IM
60
Negative acute phase reactants
``` Albumin Prealbumin Retinol binding protein transferrin Transcortin Transthyretin ```
61
Causes of decreased surfactant
Pulmonary artery occlusion 100% O2 inhalation Cigarette smoking
62
Neruoendocrine tumors of lung
``` Small cell Ca Large cell Ca Carcinoid Typical Atypical Benign tumorlets ```
63
Diff btw typical and atypical carcinoid
p53 mutation BCL2/BAX imbalance Seen in atypical carcinoid
64
Markers of Neruoendocrine tumors
``` Chromogranin Synaptophysin CD56 TTF1 CK cocktail ```
65
Normal bilirubin in blood
Unconjugated bilirubin
66
Rate limiting step in bilirubin metabolism
Excretion into bile
67
Total Hb content in body
900gm in 70kg man
68
Trace element deficiency causing impaired wound healing
``` Zinc Copper Calcium Manganese Iron ```
69
Vitamin deficiency causing impaired wound healing
Vit A and C
70
Neoplasms causing DIC
Pancreas Stomach Lung Prostate
71
Infectious causes of DIC
``` Gram negative sepsis Meningococcimia Aspergillosis Histoplasmosis RMSF Malaria ```
72
Most common manifestation of heparin overdose
Hematuria

PGI (16 decks)

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