8.7.2013(pathology)60

Question 0

Caspase 1

Answer 0

ICE

interleukin 1 beta converting enzyme

Question 1

Caspases are

Answer 1

Cysteine dependant Aspartate directed proteases

Question 2

Chromosomal alterations in oncocytoma

Answer 2

Deletions at 10q

Question 3

Mutations in Dyskeratosis congenita

Answer 3

X linked - Dyskerin

AD- hTERC,hTERT(telomerase)

Question 4

Histological types of malignant mesothelioma

Answer 4

Epithelial
Fibrous(Sarcomatoid)
Biphasic/mixed type

Question 5

Gold standard for diagnosis of malignant mesothelioma

Answer 5

EM appearance of long branching microvilli

Question 6

IHC of mesothelioma

Answer 6

Pankeratin
Keratin 5/6
Calretinin
WT1
Negative for epithelial markers like CEA,CD15

Question 7

Breast changes without increased risk of malignancy

Answer 7

Duct ectasia
Cysts
Apocrine changes 
  Mild hyperplasia
  Adenosis
Fibroadenoma without complex features
Sclerosing adenosis
Intraductal papilloma

Question 8

Breast changes associated with increased risk of malignancy

Answer 8

Florid hyperplasia
Atypical lobular hyperplasia
Atypical ductal hyperplasia
Ductal involvement by cells of atypical ductal hyperplasia(highest risk next only to in situ lesions)

Question 9

Syndromes associated with breast cancer

Answer 9

Li fraumeni 
Peutz jegher (STK11/LKB1)
Cowden
Muir torre(MSH2/MLH1)
Ataxia telangiectasia

Question 10

Full name of bloom Richardson grading

Answer 10

Nottingham combined histologic grade of Elston Ellis modification of the scarf bloom Richardson grading system

Question 11

HLA associated with juvenile Pauciarticular arthritis

Answer 11

DR8

DR5

Question 12

HLA associated with rheumatoid arthritis

Answer 12

DR4

Question 13

HLA associated with sjogren syndrome

Answer 13

DR3

Question 14

HLA associated with SLE

Answer 14

Caucasian DR3

Japanese DR2

Question 15

HLA associated with celiac disease

Answer 15

DQ2

Question 16

HLA associated with dermatitis herpetiformis

Answer 16

DR3

Question 17

HLA associated with chronic active hepatitis

Answer 17

DR3

Question 18

HLA associated with psoriasis vulgaris

Answer 18

Cw6

Question 19

HLA associated with Pemphigus vulgaris

Answer 19

DR4

DQ1

Question 20

HLA associated with Bullous pemphigoid

Answer 20

DQ7

Question 21

HLA associated with DM1

Answer 21

DR2
DR3
DR4(commonly associated)
DQ8

Question 22

HLA associated with graves disease

Answer 22

B8

DR3

Question 23

HLA associated with adrenal insufficiency

Answer 23

DR3

Question 24

HLA associated with myasthenia gravis

Answer 24

B8 | DR3

Question 25

HLA associated with multiple sclerosis

Answer 25

DR2

Question 26

HLA associated with Behcet disease

Answer 26

B51

Question 27

HLA associated with congenital adrenal hyperplasia

Answer 27

B47

Question 28

HLA associated with narcolepsy

Answer 28

DR2

Question 29

HLA associated with goodpasture syndrome

Answer 29

DR2

Question 30

Metastasis to heart arise from

Answer 30

``` Lung Breast Melanoma Leukemia Lymphoma ```

Question 31

Appearance of amyloid in different stains

Answer 31

``` H & E- pink,hyaline,homogenous Methyl violet/crystal violet- metachromasia Congo red Thioflavin T and S Toludene blue - orthochromatic blue Alcian blue- blue green PAS- pink ```

Question 32

Peutz jegher syndrome malignancy risk

Answer 32

2-10% risk for cancer of intestinal tract

Question 33

Tumors in PJ syndrome

Answer 33

``` Ca breast Ca lung Ca thyroid Ca cervix Ca Fallopian tube Ca ovary Ca pancreas Ca GB Ca Billiary tract Ca testis ```

Question 34

Most common GIT polyp

Answer 34

Hyperplastic polyp

Question 35

Most common hamartomatous polyp

Answer 35

Juvenile polyposis syndrome

Question 36

Which is most common ? FAP HNPCC

Answer 36

HNPCC but FAP is more malignant(100%)

Question 37

Surveillance for FAP and HNPCC

Answer 37

FAP 15 yrs | HNPCC 25 yrs or 10 years earlier of first degree relative developing polyps

Question 38

Tumors in Cowden syndrome

Answer 38

Breast(50%) | Thyroid

Question 39

Most common site of peutz jeghers syndrome

Answer 39

Jejunum

Question 40

Diff btw FAP and HNPCC in GIT malignancies

Answer 40

FAP Benign Gastric polyp Gall bladder Ca