3/6/2015

Question 1

what does corticosteroids do to skin?

Answer 1

thin skin

Question 2

besides decreasing adrenergic effects in thyrotoxicosis, what do beta blockers do?

Answer 2

decrease T4->T3 conversion by iodothyronine deiodinase

Question 3

what is the fxn of perchlorate and pertechnetate

Answer 3

inhibit Na/I channel (reduce I uptake) in thyroid)

Question 4

what is restless leg syndrome

Answer 4

urge to move legs, relief with movement. treated with dopamine agonists

Question 5

drugs associated with serotonin syndrome?

Answer 5

antidepressants (SSRI, MAOinhibitors, TCA, 5HT, Norepi ireuptake inhib), tramadol, odansetron, linezolid, triptans

Question 6

what are signs of serotonin syndrome?

Answer 6

hyprreflexia, clonus, rigidity
hyperthermia, tachycard, diaphoresis
agitiation and confusion

Question 7

how does warfarin work?

Answer 7

inhibits vit K depenet CARBOXYLATION of GLUTAMIC ACID residues on clotting factors 2, 7, 9, 10

Question 8

positive vs negative psychotic symptoms?

Answer 8

posotive: delusions and hallucinations
negative: social withdrawal, anhedonia, blunted affect, and poor initiative

Question 9

what is clozapine

Answer 9

antipsychotic that acts on D4 NOT D2 receptors. Can cause life threatening agranulocytosis so need weekly WBC. Can also cause Seizures

Question 10

treatment for alzheimers?

Answer 10

donepezil: cholinesterase inhibitors
vitamin E: antioxidant (alpha tocopherol)
memantine: NMDA receptor antagonists

Question 11

major side effect of nitroprusside? treatment?

Answer 11

metabolized to cyanide and can cause cyanide toxicity. give sodium thiosulfate to treat the toxicity

Question 12

treatment for essential tremor (familial tremore)…believed to be inherited in autosomal dominant fashion

Answer 12

propanolol

Question 13

what drug for tonic clonic and silent seizure?

Answer 13

valproate