3-Virology Flashcards
(111 cards)
2
Q
All viruses are haploid EXCEPT
A
Retroviruses
3
Q
All DNA viruses have double-stranded DNA EXCEPT
A
Parvovirus
4
Q
All RNA viruses have single-stranded RNA EXCEPT
A
Reoviruses
5
Q
All double-stranded DNA viruses are icosahedral EXCEPT
A
Poxvirus
6
Q
Father of vaccination
A
Edward Jenner
7
Q
Creutzfeldt-Jakob disease (cognitive or cerebellar?)
A
Cognitive
8
Q
Kuru (cognitive or cerebellar?)
A
Cerebellar
9
Q
Erythema infectiosum
A
Parvovirus B19
10
Q
Aplastic anemia in children with sickle cell
A
Parvovirus B19
11
Q
MCC of viral conjunctivitis
A
Adenovirus
12
Q
How many adenovirus serotypes?
A
41
13
Q
Koilochtes
A
HPV
14
Q
Gene involve in the suppression of tumor suppressor genes in HPV
A
E6, E7
15
Q
Condylomata acuminata
A
HPV
16
Q
Tzank smear
A
HSV
17
Q
What do you see in Tzank smear?
A
Multinucleated giant cells
18
Q
HSV on brain biopsy
A
Cowdry type A
19
Q
Temporal lobe encephalitis
A
HSV-1
20
Q
Thalamic encephalitis
A
Japanese B encephalitis
21
Q
Centrifugal rash 2 weeks postrespiratory infection
A
VZV
22
Q
Dewdrop on a rose appearance
A
VZV
23
Q
Site of latency in VZV
A
Dorsal root ganglion
24
Q
Reactivated VZV
A
Shingles
25
Q
MCC of congenital abnormalities
A
CMV
26
Heterophil-negative mononucleosis
CMV, toxoplasmosis gondii
27
DOC of HSV
Acyclovir
28
Rare complication: splenic rupture
EBV
29
Kissing disease
EBV
30
Burkitt's lymphoma in Africans
EBV
31
Hairy cell leukoplakia in HIV
EBV
32
Nasopharyngeal carcinoma in Chinese
EBV
33
Heterophil-positive mononucleosis
EBV
34
DOC of Hepatitis B
Lamivudine
35
Dane particles
Hepatitis B
36
Necrotic hepatocytes in Hepatitis B
Councilman Bodies
37
Necrotic hepatocytes in alcoholic hepatitis
Mallory bodies
38
Blueberry muffin appearance
Congenital rubella, CMV, disseminated neuroblastoma
39
Roseola infantum AKA
Exanthem sobitum
40
Marker of Hepatitis B infection
HBsAg
41
Marker of infectivity in Hepatitis B
HBeAg
42
Marker of active viral replication in Hepatitis B
HBeAg
43
Marker for seroconversion in Hepatitis B
Anti-HBsAg
44
The only marker during the "window" period in Hepatitis B
Anti-HBcAg
45
Replicates in the motor neuron in the anterior horn cells of the spinal cord
Poliovirus
46
MCC in viral myocarditis and pericarditis
Coxsackie type B
47
Herpangina, hand-foot-and-mouth disease, hemorrhagic conjunctivitis
Coxsackie type A
48
MCC of viral meningitis
Coxsackie virus
49
High mortaility in pregnant women
Hepatitis E virus
50
MCC of nonbacterial diarrhea in adults
Norwalk virus
51
Norwalk virus AKA
Norovirus
52
MCC of childhood diarrhea
Rotavirus
53
Capable of undergoing antigenic shifts and drifts
Influenza virus
54
Latest strain of influenza virus
H7N9
55
Warthin-Finkeldy bodies
Measles
56
Rubeola
Measles
57
Koplik spots
Measles
58
SSPE
Measles
59
Damson's disease
Measles
60
Tender swelling of the parotid glands
Parotitis
61
Causes parotitis
Mumps
62
Complications of mumps
Orchitis, meningitis
63
MCC of pneumonia and bronchiolitis in infants
RSV
64
DOC of Actinomycosis
Penicillin
65
DOC of Nocardia
Sulfa drugs
66
Laryngotracheobronchitis
Parainfluenza virus
67
Steeple sign
Laryngotracheobronchitis
68
DOC for Laryngotracheobronchitis
Racemic epinephrine
69
Negri bodies
Rabies virus
70
Fatality in rabies when encephalitis develops is secondary to?
Early brainstem dysfunction
71
SARS
Coronavirus
72
Horseshoe bats
SARS; coronavirus
73
Virus binds to ACE-2 receptor
Coronavirus
74
CXR finding in SARS
"Ground-glass" appearance
75
Vector for dengue fever
Aedes aegypti
76
Gold standard test for DF
Dengue RTPCR test
77
Breakbone fever
Dengue fever
78
Herman's rash
Dengue fever
79
Most prevalent blood-borne pathogen
Hepatitis C virus
80
Main cause of essential mixed cryoglobulinemia
Hepatitis C virus
81
"3 day" measles
German measles
82
German measles
Rubella
83
Measles with Posterior auricular LAD
Rubella
84
Congenital rubella syndrome
PDA, congenital cataracts, sensorineural deafness, mental retardation
85
(HIV) gag
p24, p7, p17
86
(HIV) nucleocapsid
p24, p7
87
(HIV) matrix
p17
88
(HIV) pol
Reverse transcriptase, protease, integrase
89
(HIV) transcribes RNA genome into DNA
Reverse transcriptase
90
(HIV) cleaves precursor polypeptides
Protease
91
(HIV) integrates viral DNA into host cell DNA
Integrase
92
(HIV) env
gp120, gp41
93
(HIV) attachment to CD4 protein
gp120
94
(HIV) antigenicity changes rapidly
gp120
95
(HIV) fusion with host cell
gp41
96
(HIV) activation of transcription of viral genes
tat
97
(HIV) transport of late mRNAs to cytoplasm
rev
98
(HIV) decreases CD4 and class I MHC proteins (MUST KNOW!!!)
nef
99
(HIV) enhances virion release
vpu
100
(HIV) enhances hypermutation
vif
101
(HIV) transport in nondividing cells
vpr
102
HIV acquired through sexual intercourse, blood, or perinatally
Phase 0-Infection
103
Rapid viral replication but HIV test negative
Phase 1-Window period
104
Peak of viral load, positive HIV test, mild flu-like illness, lasting for 1-2 weeks
Phase 2-Seroconversion
105
Asymptomatic, CD4 goes down, lasts for 1-15 years
Phase 3-Latent period
106
CD4 500-200, lasts for 5 years, mild mucocutaneous, dermatologic and hematologic illnesses
Phase 4-Early symptomatic
107
CD4 less than 200, lasts 2 years, AIDS defining illnesses develop
Phase 5-AIDS
108
CD4 less than 500
M. tuberculosis, HSV, C. albicans, HHV-8
109
CD4 less than 200
P. jiroveci, T. gondii, C. neoformans, C. immitis, C. parvum
110
CD4 less than 50
M. avium, H. capsulatum, CMV
111
MCC of death in HIV
Disseminated tuberculosis
112
MCC of blindness in HIV
CMV retinitis
