012015 gut immunity

Question 1

host defense barriers

Answer 1

• -immediate (existing physical and chemical barriers)
• -early (existing innate immune cells and mediators)
• -late (actiavtion of appropriate adaptive immune cells and mediators)

Question 2

cell associated pattern recognition receptors

Answer 2

TLRs
NLRs (in cytoplasm)
mannose receptors

Question 3

soluble pattern recognition receptors

Answer 3

C reactive protein
mannose binding lectin
complement - C3
IgM

these are all located in the plasma

Question 4

fxn of TLRs

Answer 4

activate genes necessary for defense against bacterial (TNF, IL1, IL6), viral (IFNalpha/beta), or fungal organism

Question 5

innate immune response for bacteria

Answer 5

neutrophils
DCs
activated macrophage
cytokines (IL12, TNF, IL1, IL6, TGFbeta)

Question 6

what leads to differentiation to a Th17 cell?

Answer 6

TGFbeta, IL6, IL23

Question 7

review of cytokines

Answer 7

see slide 26

Question 8

classical pathway for complement involves

Answer 8

IgM coating bacteria

Question 9

lectin pathway for complement involves

Answer 9

mannose binding lectin coating bacteria

Question 10

C3b plays what role

Answer 10

opsonization and phagocytosis

Question 11

C5a and C3a serve what role

Answer 11

inflam

Question 12

recognition receptors for intestinal viruses

Answer 12

TLRs
NLRs
antibody (IgM)

Question 13

anti viral innate immune response

Answer 13

epithelial cells secrete IFNa/b to boost antiviral immunity in neighboring cells

DC engulfs and takes to Peyer’s patch. causes native T cell to become CD8 CTL. also causes naitve T cells to become Th1 cells, which activate macrophages and naive B cells through IFNgamma.

NK cell secretes IFNgamma

Question 14

innate immuneo response against parasites

Answer 14

granulocytes are important (eosinophil, basophil, mast cells). granulocytes are activated by Ag-bound IgE binding cell surface FceRI receptor–this depends on previous exposure to an antigen

parasites are too big to be engulfed!