012215 IBD Flashcards
1
Q
ulcerative colitis
A
continuous inflam colon only superficial inflam risk of cancer extraintestinal manifestations goes from rectum to more proximal
2
Q
clinical presentation of UC
A
diarrhea, typically bloody w mucus abdominal pain loss of appetite, weight loss fever fatigue urgency for bowel mvmt children-developmental failure
3
Q
endoscopic findings of UC
A
erythema friability (when touched, bleeds) pseudopolyps (benign) erosions ulcers (in severe cases) cecal patch backwash ileitis (only w pancolitis)
etc
4
Q
Crohn’s dis
A
pathcy inflam can involve anywhere from mouth to anus full thickness inflam (all layers of bowel) cobblestone look fistulae-peritoneum, bladder strictures and surgery (due to inflam) extraintestinal manifestations
5
Q
most common site for Crohn’s dis
A
terminal ileum, cecum
6
Q
clinical presentation of Crohn’s dis
A
abd pain diarrhea weight loss anorexia vomiting rectal bleeding stunted growth in children fevers
7
Q
3 major endoscopic findings SPECIFIC for Crohn’s dis
A
aphthous ulcers (canker sores)
cobblestoning
discontinuous lesions
8
Q
you see ulcers more often with Crohn’s dis or UC?
A
Crohn’s
9
Q
UC always affects the
A
rectum
10
Q
fistulas and strictures are seen in Crohn’s and not UC b/c
A
Crohn’s has full thickness inflam
11
Q
granulomas on biopsy favors Crohn’s or UC?
A
Crohn’s
12
Q
extraintestinal manifestations of IBD
A
acute arthropathy erythema nodosum choledocholithiasis ocular complications sacroilliits ankylosing spondylitis pyoderma gangrenosum PSC (more UC than Crohn's)
13
Q
pathogenesis of IBD
A
genetic-NOD2 mutations
mucosal immune responses (Th17 cells)
epithelial defects (tight jxns)
microbiota (rxns against microbiota)
