Pharmacogenomics Flashcards
0
Q
Pharmacogenomics vs pharmacogenetics
A
Pharmacogenetics- the study of the variability of a drug response due to genetic factors
Pharmacogenomics- the development of a drug based on knowledge of genetic determinants
1
Q
The response of meds from one to another varies. This is called what?
A
Individual variability
2
Q
What is SNP? What’s its impact?
A
Single nucleotide polymorphism– variations in a single nucleotide in a DNA sequence can effect:
pK- drug metabolism/plasma concentration
PD- drug-receptor binding
3
Q
Explain codeine and nortryptiline in ultra metabolizers
A
Fast vs prodrug
